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Decarboxylation-based traceless linking with Aroyl acrylic acids

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β-Keto carboxylic acids are known to decarboxylate readily. In our pursuit to synthesize β-indolinyl propiophenones, we have exploited this chemistry as a mean of establishing a traceless handle. 2-Aroyl acrylic acids have been esterified to a trityl resin, after which Michael-type addition of indolines have been performed. Upon cleavage, the products are decarboxylated, and the β-indolinyl propiophenones are isolated. The reaction conditions have been optimized, and a small library has been prepared.

OriginalsprogEngelsk
TidsskriftTetrahedron Letters
Vol/bind39
Udgave nummer15
Sider (fra-til)2207-2210
Antal sider4
ISSN0040-4039
DOI
StatusUdgivet - 9 apr. 1998

ID: 131118136