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Decreased incidence of myelomeningocele at birth: Effect of folic acid recommendations or prenatal diagnostics?

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Standard

Decreased incidence of myelomeningocele at birth : Effect of folic acid recommendations or prenatal diagnostics? / Clemmensen, Dorte; Thygesen, Mathias; Rasmussen, Mikkel Mylius; Fenger-Grøn, Morten; Petersen, Olav B.; Mosdal, Claus.

I: Child's Nervous System, Bind 27, Nr. 11, 2011, s. 1951-1955.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Clemmensen, D, Thygesen, M, Rasmussen, MM, Fenger-Grøn, M, Petersen, OB & Mosdal, C 2011, 'Decreased incidence of myelomeningocele at birth: Effect of folic acid recommendations or prenatal diagnostics?', Child's Nervous System, bind 27, nr. 11, s. 1951-1955. https://doi.org/10.1007/s00381-011-1473-2

APA

Clemmensen, D., Thygesen, M., Rasmussen, M. M., Fenger-Grøn, M., Petersen, O. B., & Mosdal, C. (2011). Decreased incidence of myelomeningocele at birth: Effect of folic acid recommendations or prenatal diagnostics? Child's Nervous System, 27(11), 1951-1955. https://doi.org/10.1007/s00381-011-1473-2

Vancouver

Clemmensen D, Thygesen M, Rasmussen MM, Fenger-Grøn M, Petersen OB, Mosdal C. Decreased incidence of myelomeningocele at birth: Effect of folic acid recommendations or prenatal diagnostics? Child's Nervous System. 2011;27(11):1951-1955. https://doi.org/10.1007/s00381-011-1473-2

Author

Clemmensen, Dorte ; Thygesen, Mathias ; Rasmussen, Mikkel Mylius ; Fenger-Grøn, Morten ; Petersen, Olav B. ; Mosdal, Claus. / Decreased incidence of myelomeningocele at birth : Effect of folic acid recommendations or prenatal diagnostics?. I: Child's Nervous System. 2011 ; Bind 27, Nr. 11. s. 1951-1955.

Bibtex

@article{057249bf5a734328a61bfa29da7cb43d,
title = "Decreased incidence of myelomeningocele at birth: Effect of folic acid recommendations or prenatal diagnostics?",
abstract = "Purpose: In Denmark, prevention to reduce the spina bifida birth rate has focused on two areas: folic acid supplementation (1997) and changes in the national ultrasonography screening programme (2004). Myelomeningocele (MMC) is the most severe malformation among the spina bifidas. Taking into consideration the potential negative effect of high-dose folic acid consumption, we found a need to look into the effectiveness of these two strategies in our complete MMC population. Methods: All spina bifida patients born in the western part of Denmark are differentiated into proper subgroups based on MR imaging, giving us a unique chance to study a true MMC population. The total number of the group of MMC children since 1983 is 121. One hundred and eight (89{\%}) parents answered a questionnaire. Results: Following the changes in the prenatal ultrasonography screening programme in 2004, a significant decline of 60{\%} live birth MMC per year was noted, incidence rate ratio (IRR)=40{\%} (22-73{\%}), p=0.3{\%}. We found no change in MMC birth rate after introduction of folic acid supplementation, IRR=121{\%} (81-181{\%}), p=36{\%}. Conclusion: Our findings demonstrate no effect of folic acid recommendation due to lack of compliance among women of reproductive age in Denmark. However, we found an improved early detection rate of prenatal MMC by high-quality ultrasonography. Subsequent early termination of pregnancy has led to a significant reduction of birth rate of babies with MMC.",
keywords = "Folic acid, Myelomeningocele, Recommendations, Screening programme, Ultrasonography",
author = "Dorte Clemmensen and Mathias Thygesen and Rasmussen, {Mikkel Mylius} and Morten Fenger-Gr{\o}n and Petersen, {Olav B.} and Claus Mosdal",
year = "2011",
doi = "10.1007/s00381-011-1473-2",
language = "English",
volume = "27",
pages = "1951--1955",
journal = "Child's Nervous System",
issn = "0256-7040",
publisher = "Springer",
number = "11",

}

RIS

TY - JOUR

T1 - Decreased incidence of myelomeningocele at birth

T2 - Effect of folic acid recommendations or prenatal diagnostics?

AU - Clemmensen, Dorte

AU - Thygesen, Mathias

AU - Rasmussen, Mikkel Mylius

AU - Fenger-Grøn, Morten

AU - Petersen, Olav B.

AU - Mosdal, Claus

PY - 2011

Y1 - 2011

N2 - Purpose: In Denmark, prevention to reduce the spina bifida birth rate has focused on two areas: folic acid supplementation (1997) and changes in the national ultrasonography screening programme (2004). Myelomeningocele (MMC) is the most severe malformation among the spina bifidas. Taking into consideration the potential negative effect of high-dose folic acid consumption, we found a need to look into the effectiveness of these two strategies in our complete MMC population. Methods: All spina bifida patients born in the western part of Denmark are differentiated into proper subgroups based on MR imaging, giving us a unique chance to study a true MMC population. The total number of the group of MMC children since 1983 is 121. One hundred and eight (89%) parents answered a questionnaire. Results: Following the changes in the prenatal ultrasonography screening programme in 2004, a significant decline of 60% live birth MMC per year was noted, incidence rate ratio (IRR)=40% (22-73%), p=0.3%. We found no change in MMC birth rate after introduction of folic acid supplementation, IRR=121% (81-181%), p=36%. Conclusion: Our findings demonstrate no effect of folic acid recommendation due to lack of compliance among women of reproductive age in Denmark. However, we found an improved early detection rate of prenatal MMC by high-quality ultrasonography. Subsequent early termination of pregnancy has led to a significant reduction of birth rate of babies with MMC.

AB - Purpose: In Denmark, prevention to reduce the spina bifida birth rate has focused on two areas: folic acid supplementation (1997) and changes in the national ultrasonography screening programme (2004). Myelomeningocele (MMC) is the most severe malformation among the spina bifidas. Taking into consideration the potential negative effect of high-dose folic acid consumption, we found a need to look into the effectiveness of these two strategies in our complete MMC population. Methods: All spina bifida patients born in the western part of Denmark are differentiated into proper subgroups based on MR imaging, giving us a unique chance to study a true MMC population. The total number of the group of MMC children since 1983 is 121. One hundred and eight (89%) parents answered a questionnaire. Results: Following the changes in the prenatal ultrasonography screening programme in 2004, a significant decline of 60% live birth MMC per year was noted, incidence rate ratio (IRR)=40% (22-73%), p=0.3%. We found no change in MMC birth rate after introduction of folic acid supplementation, IRR=121% (81-181%), p=36%. Conclusion: Our findings demonstrate no effect of folic acid recommendation due to lack of compliance among women of reproductive age in Denmark. However, we found an improved early detection rate of prenatal MMC by high-quality ultrasonography. Subsequent early termination of pregnancy has led to a significant reduction of birth rate of babies with MMC.

KW - Folic acid

KW - Myelomeningocele

KW - Recommendations

KW - Screening programme

KW - Ultrasonography

U2 - 10.1007/s00381-011-1473-2

DO - 10.1007/s00381-011-1473-2

M3 - Journal article

C2 - 21552997

AN - SCOPUS:80054768577

VL - 27

SP - 1951

EP - 1955

JO - Child's Nervous System

JF - Child's Nervous System

SN - 0256-7040

IS - 11

ER -

ID: 228739173