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Delay in blood sampling for routine newborn screening is associated with increased risk of schizophrenia

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Delay in blood sampling for routine newborn screening is associated with increased risk of schizophrenia. / Nordentoft, Merete; Larsen, Janne Tidselbak; Pedersen, Carsten Bøcker; Sørensen, Holger Jelling; Hollegaard, Mads Villiam; Hougaard, David Michael; Mortensen, Preben Bo; Petersen, Liselotte.

I: Schizophrenia Research, Bind 162, Nr. 1-3, 03.2015, s. 90-6.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Nordentoft, M, Larsen, JT, Pedersen, CB, Sørensen, HJ, Hollegaard, MV, Hougaard, DM, Mortensen, PB & Petersen, L 2015, 'Delay in blood sampling for routine newborn screening is associated with increased risk of schizophrenia', Schizophrenia Research, bind 162, nr. 1-3, s. 90-6. https://doi.org/10.1016/j.schres.2015.01.001

APA

Nordentoft, M., Larsen, J. T., Pedersen, C. B., Sørensen, H. J., Hollegaard, M. V., Hougaard, D. M., Mortensen, P. B., & Petersen, L. (2015). Delay in blood sampling for routine newborn screening is associated with increased risk of schizophrenia. Schizophrenia Research, 162(1-3), 90-6. https://doi.org/10.1016/j.schres.2015.01.001

Vancouver

Nordentoft M, Larsen JT, Pedersen CB, Sørensen HJ, Hollegaard MV, Hougaard DM o.a. Delay in blood sampling for routine newborn screening is associated with increased risk of schizophrenia. Schizophrenia Research. 2015 mar;162(1-3):90-6. https://doi.org/10.1016/j.schres.2015.01.001

Author

Nordentoft, Merete ; Larsen, Janne Tidselbak ; Pedersen, Carsten Bøcker ; Sørensen, Holger Jelling ; Hollegaard, Mads Villiam ; Hougaard, David Michael ; Mortensen, Preben Bo ; Petersen, Liselotte. / Delay in blood sampling for routine newborn screening is associated with increased risk of schizophrenia. I: Schizophrenia Research. 2015 ; Bind 162, Nr. 1-3. s. 90-6.

Bibtex

@article{7e294cc376e7496ea0e807e0a022c3c8,
title = "Delay in blood sampling for routine newborn screening is associated with increased risk of schizophrenia",
abstract = "BACKGROUND: The Danish Neonatal Screening Biobank, containing dried blood spot samples from all newborn in Denmark, is a unique source of data that can be utilized for analyses of genetic and environmental exposures related to schizophrenia and other mental disorders. In previous analyses, we have found that early and late blood sampling, compared to sampling at day 5, was associated with increased risk of schizophrenia. As delay in sampling of blood for neonatal screening cannot in itself influence the risk of schizophrenia, it must be seen as a proxy for unknown underlying causes responsible for this association. Therefore, we investigated whether the increased risk can be explained by other risk factors for schizophrenia.METHODS: A case-control design was applied. A total of 846 cases with schizophrenia were selected from the Danish Psychiatric Case Register. One control was selected for each case, matched on sex and exact date of birth.RESULTS: Both early and late blood sampling was associated with increased risk for schizophrenia. Compared to blood sampling at day 5, sampling at days 0 to 4 after birth was associated with an incidence rate ratio (IRR) of 1.46 (95% CI 1.15-1.87) for development of schizophrenia, and sampling at days 6 to 9 and at days 10 to 53 was associated with an IRR of 1.5 (95% CI 1.13-1.98) and 3.00 (95% CI 1.59-5.67), respectively. After adjusting the estimates for place of birth, both parents' psychiatric illness, maternal and paternal age, parents' country of origin, child admission, and parental education and income, the estimates were slightly different. Thus, blood collection at 0-4days was associated with an IRR of 1.27 (95% CI 0.94-1.71), 6-9days 1.31 (95% CI 0.94-1.84) and 10+days 3.52 (95% CI 1.50 to 8.24).DISCUSSION: After adjusting risk estimates for well-known risk factors, delay in sampling of blood for neonatal screening was associated with unexplained increased risk of schizophrenia. Thus, a key finding is that age at test is a proxy for unobserved risk factors for schizophrenia due to unexplained reasons for late blood sampling. Date of sampling will be included in future analyses of genetic and environmental risk factors.",
keywords = "Age Factors, Biological Specimen Banks, Blood Specimen Collection, Case-Control Studies, Denmark, Female, Humans, Infant, Newborn, Male, Neonatal Screening, Risk Factors, Schizophrenia, Socioeconomic Factors, Time Factors",
author = "Merete Nordentoft and Larsen, {Janne Tidselbak} and Pedersen, {Carsten B{\o}cker} and S{\o}rensen, {Holger Jelling} and Hollegaard, {Mads Villiam} and Hougaard, {David Michael} and Mortensen, {Preben Bo} and Liselotte Petersen",
note = "Copyright {\textcopyright} 2015 Elsevier B.V. All rights reserved.",
year = "2015",
month = mar,
doi = "10.1016/j.schres.2015.01.001",
language = "English",
volume = "162",
pages = "90--6",
journal = "Schizophrenia Research",
issn = "0920-9964",
publisher = "Elsevier",
number = "1-3",

}

RIS

TY - JOUR

T1 - Delay in blood sampling for routine newborn screening is associated with increased risk of schizophrenia

AU - Nordentoft, Merete

AU - Larsen, Janne Tidselbak

AU - Pedersen, Carsten Bøcker

AU - Sørensen, Holger Jelling

AU - Hollegaard, Mads Villiam

AU - Hougaard, David Michael

AU - Mortensen, Preben Bo

AU - Petersen, Liselotte

N1 - Copyright © 2015 Elsevier B.V. All rights reserved.

PY - 2015/3

Y1 - 2015/3

N2 - BACKGROUND: The Danish Neonatal Screening Biobank, containing dried blood spot samples from all newborn in Denmark, is a unique source of data that can be utilized for analyses of genetic and environmental exposures related to schizophrenia and other mental disorders. In previous analyses, we have found that early and late blood sampling, compared to sampling at day 5, was associated with increased risk of schizophrenia. As delay in sampling of blood for neonatal screening cannot in itself influence the risk of schizophrenia, it must be seen as a proxy for unknown underlying causes responsible for this association. Therefore, we investigated whether the increased risk can be explained by other risk factors for schizophrenia.METHODS: A case-control design was applied. A total of 846 cases with schizophrenia were selected from the Danish Psychiatric Case Register. One control was selected for each case, matched on sex and exact date of birth.RESULTS: Both early and late blood sampling was associated with increased risk for schizophrenia. Compared to blood sampling at day 5, sampling at days 0 to 4 after birth was associated with an incidence rate ratio (IRR) of 1.46 (95% CI 1.15-1.87) for development of schizophrenia, and sampling at days 6 to 9 and at days 10 to 53 was associated with an IRR of 1.5 (95% CI 1.13-1.98) and 3.00 (95% CI 1.59-5.67), respectively. After adjusting the estimates for place of birth, both parents' psychiatric illness, maternal and paternal age, parents' country of origin, child admission, and parental education and income, the estimates were slightly different. Thus, blood collection at 0-4days was associated with an IRR of 1.27 (95% CI 0.94-1.71), 6-9days 1.31 (95% CI 0.94-1.84) and 10+days 3.52 (95% CI 1.50 to 8.24).DISCUSSION: After adjusting risk estimates for well-known risk factors, delay in sampling of blood for neonatal screening was associated with unexplained increased risk of schizophrenia. Thus, a key finding is that age at test is a proxy for unobserved risk factors for schizophrenia due to unexplained reasons for late blood sampling. Date of sampling will be included in future analyses of genetic and environmental risk factors.

AB - BACKGROUND: The Danish Neonatal Screening Biobank, containing dried blood spot samples from all newborn in Denmark, is a unique source of data that can be utilized for analyses of genetic and environmental exposures related to schizophrenia and other mental disorders. In previous analyses, we have found that early and late blood sampling, compared to sampling at day 5, was associated with increased risk of schizophrenia. As delay in sampling of blood for neonatal screening cannot in itself influence the risk of schizophrenia, it must be seen as a proxy for unknown underlying causes responsible for this association. Therefore, we investigated whether the increased risk can be explained by other risk factors for schizophrenia.METHODS: A case-control design was applied. A total of 846 cases with schizophrenia were selected from the Danish Psychiatric Case Register. One control was selected for each case, matched on sex and exact date of birth.RESULTS: Both early and late blood sampling was associated with increased risk for schizophrenia. Compared to blood sampling at day 5, sampling at days 0 to 4 after birth was associated with an incidence rate ratio (IRR) of 1.46 (95% CI 1.15-1.87) for development of schizophrenia, and sampling at days 6 to 9 and at days 10 to 53 was associated with an IRR of 1.5 (95% CI 1.13-1.98) and 3.00 (95% CI 1.59-5.67), respectively. After adjusting the estimates for place of birth, both parents' psychiatric illness, maternal and paternal age, parents' country of origin, child admission, and parental education and income, the estimates were slightly different. Thus, blood collection at 0-4days was associated with an IRR of 1.27 (95% CI 0.94-1.71), 6-9days 1.31 (95% CI 0.94-1.84) and 10+days 3.52 (95% CI 1.50 to 8.24).DISCUSSION: After adjusting risk estimates for well-known risk factors, delay in sampling of blood for neonatal screening was associated with unexplained increased risk of schizophrenia. Thus, a key finding is that age at test is a proxy for unobserved risk factors for schizophrenia due to unexplained reasons for late blood sampling. Date of sampling will be included in future analyses of genetic and environmental risk factors.

KW - Age Factors

KW - Biological Specimen Banks

KW - Blood Specimen Collection

KW - Case-Control Studies

KW - Denmark

KW - Female

KW - Humans

KW - Infant, Newborn

KW - Male

KW - Neonatal Screening

KW - Risk Factors

KW - Schizophrenia

KW - Socioeconomic Factors

KW - Time Factors

U2 - 10.1016/j.schres.2015.01.001

DO - 10.1016/j.schres.2015.01.001

M3 - Journal article

C2 - 25631455

VL - 162

SP - 90

EP - 96

JO - Schizophrenia Research

JF - Schizophrenia Research

SN - 0920-9964

IS - 1-3

ER -

ID: 162684731