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Delayed early proprioceptive information processing in schizophrenia

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It was first suggested that disordered proprioception was a core feature of schizophrenia by Sandor Rado in 1953. Using a recently designed proprioceptive event-related potential paradigm based on a change of load, we studied 12 unmedicated male out-patients with schizophrenia and 24 controls. In the patients, the early contralateral parietal activity was delayed and later central activity had increased amplitude, but gating was unaffected. The results could be understood within the "deficiency of corollary discharge" model of schizophrenia but not within the "filtering" theory. Further studies, including psychiatric controls, are necessary to verify the specificity of the abnormality.
OriginalsprogEngelsk
TidsskriftBritish Journal of Psychiatry
Vol/bind189
Sider (fra-til)558-9
Antal sider2
ISSN0007-1250
DOI
StatusUdgivet - 1 dec. 2006

ID: 1101037