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Demonstration of pepsinogen C in human pancreatic islets

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Pancreatic tissue from 16 post mortem kidney donors have been examined for the content of pepsinogens. A zymogen with electrophoretic mobility, isoelectric point and molecular weight equal to that of pepsinogen C of gastric origin was found in all specimens. A comparison between pepsinogen C extracted from pancreatic tissue and gastric mucosa demonstrated immunological identity. Quantitative measurements with a radioimmunoassay showed pepsinogen C concentrations in pancreatic tissue three to 80 times higher than those of blood serum. Immunohistochemical staining gave positive reaction for pepsinogen C only in the alpha cells of the pancreatic islets.
OriginalsprogEngelsk
TidsskriftGut
Vol/bind28
Udgave nummer10
Sider (fra-til)1208-14
Antal sider7
ISSN0017-5749
StatusUdgivet - okt. 1987

ID: 47488581