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Dendritic cells modified by vitamin D: Future immunotherapy for autoimmune diseases

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  • Ayako Wakatsuki Pedersen
  • Mogens Helweg Claesson
  • Mai-Britt Zocca
Dendritic cells (DCs), the most potent antigen-presenting cells of the immune system, express nuclear receptors for 1,25-dihydroxyvitamin D3 (VD3) and they are one of its main targets. In the presence of VD3, DCs differentiate into a phenotype that resembles semimature DCs, with reduced T cell costimulatory molecules and hampered IL-12 production. These VD3-modulated DCs induce T cell tolerance in vitro using multiple mechanisms such as rendering T cells anergic, dampening of Th1 responses, and recruiting and differentiating regulatory T cells. Due to their ability to specifically target pathological T cells, VD3-modulated DCs are safe and potentially more effective alternatives to currently available immunoregulatory therapies. While a number of considerations remain, including the establishment of a reliable quality control measure to ensure the safety and efficacy of VD3-DCs in vivo and the optimal frequency, dose, and route of DC administration to achieve therapeutic effects in humans, adoptive VD3-DC transfer represents one of the most promising approaches to future treatment of autoimmune diseases.

OriginalsprogEngelsk
BogserieVitamins and Hormones
Vol/bind86
Sider (fra-til)63-82
Antal sider20
ISSN0083-6729
DOI
StatusUdgivet - 2011

ID: 33504574