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Deposition of a model substance, Tc E-HIDA, in the oral cavity after administration of lozenges, chewing gum and sublingual tablets

Publikation: Forskning - peer reviewTidsskriftartikel

Lona Louring Christrup, S.S. Davis, C.D. Melia, I.R. Wilding, M. Frier, S.N. Rasmussen, N. Washington, C. Andersen

The deposition and clearance of a model substance, Tc E-HIDA, in the oral cavity/upper oesophagus and in the stomach after administration of lozenges, chewing gum and sublingual tablets has been followed by gamma scintigraphy in a group of healthy male volunteers. Following administration of sublingual tablets, the residence time of the model substance in the oral cavity was significantly longer than following administration of chewing gum. The residence time following administration of lozenges was found to be the shortest.
OriginalsprogEngelsk
TidsskriftInternational Journal of Pharmaceutics
Vol/bind66
Tidsskriftsnummer1-3
Sider (fra-til)169-174
Antal sider6
ISSN0378-5173
StatusUdgivet - 1 dec. 1990

ID: 46099978