Forskning ved Københavns Universitet - Københavns Universitet

Forside

Design of association studies with pooled or un-pooled next-generation sequencing data

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Su Yeon Kim, Yingrui Li, Yiran Guo, Ruiqiang Li, Johan Holmkvist, Torben Hansen, Oluf Borbye Pedersen, Jun Wang, Rasmus Nielsen

Most common hereditary diseases in humans are complex and multifactorial. Large-scale genome-wide association studies based on SNP genotyping have only identified a small fraction of the heritable variation of these diseases. One explanation may be that many rare variants (a minor allele frequency, MAF
OriginalsprogEngelsk
TidsskriftGenetic Epidemiology
Vol/bind34
Udgave nummer5
Sider (fra-til)479-491
Antal sider13
ISSN0741-0395
DOI
StatusUdgivet - 2010

ID: 35312360