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Development and descent of the testis in relation to cryptorchidism

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The testis descends in two phases. Animal studies suggest, that the transabdominal descent of the testis depends on the insulin-like hormone 3 (INSL3). Androgens are important in the inguinoscrotal testicular descent in animals and humans. In general, the cause of cryptorchidism is unknown and the aetiology is possibly multifactorial. Histological changes in cryptorchid testes demonstrate disturbed development. Conclusion: Since testicular descent is regulated by testis-derived hormones, cryptorchidism may reflect a functional defect of the testis.
OriginalsprogEngelsk
TidsskriftActa Paediatrica
Vol/bind96
Udgave nummer5
Sider (fra-til)622-7
Antal sider6
ISSN0803-5253
DOI
StatusUdgivet - 1 maj 2007

ID: 34345351