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Dialysis and Renal Transplantation in HIV-Infected Patients: a European Survey

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

  • Joan Carles Trullas
  • Amanda Mocroft
  • Federico Cofan
  • Jérome Tourret
  • Asunción Moreno
  • Corinne Isnard Bagnis
  • Christoph Andreas Fux
  • Christine Katlama
  • Peter Reiss
  • Lundgren, Jens
  • Jose Maria Gatell
  • Kirk, Ole
  • Jose M Miró
  • the EuroSIDA Investigators
OBJECTIVES:: To determine prevalence and characteristics of end-stage renal diseases (ESRD) [dialysis and renal transplantation (RT)] among European HIV-infected patients. METHODS:: Cross-sectional multicenter survey of EuroSIDA clinics during 2008. RESULTS:: Prevalence of ESRD was 0.5%. Of 122 patients with ESRD 96 were on dialysis and 26 had received a RT. Median age was 47 years, 73% were males and 43% were black. Median duration of HIV infection was 11 years. Thirty-three percent had prior AIDS; 91% were receiving antiretrovirals; and 88% had undetectable viral load. Median CD4T-cell count was 341 cells per cubic millimetre; 20.5% had hepatitis C coinfection. Most frequent causes of ESRD were HIV-associated nephropathy (46%) and other glomerulonephritis (28%). Hemodialysis (93%) was the most common dialysis modality; 34% of patients were on the RT waiting list. A poor HIV control was the reason for exclusion from RT waiting list in 22.4% of cases. All the RT recipients were all alive at the time of the survey. Acute rejection was reported in 8 patients (30%). Functioning graft was present in 21 (80%). CONCLUSIONS:: This is the first multinational cross-sectional study of ESRD among European HIV population. Low prevalence of ESRD was found. Two-thirds of patients were excluded from RT for non-HIV/AIDS-related pathologies. Most patients had a functioning graft despite a high acute rejection rate.
OriginalsprogEngelsk
TidsskriftJournal of acquired immune deficiency syndromes (1999)
Vol/bind55
Udgave nummer5
Sider (fra-til)582-589
Antal sider8
DOI
StatusUdgivet - dec. 2010

ID: 33864517