Forskning ved Københavns Universitet - Københavns Universitet


Dietary Methyl-Group Donor Intake and Breast Cancer Risk in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

  • Heleen Van Puyvelde
  • Nikos Papadimitriou
  • Joanna Clasen
  • David Muller
  • Carine Biessy
  • Pietro Ferrari
  • Jytte Halkjær
  • Kim Overvad
  • Renee T. Fortner
  • Verena Katzke
  • Matthias B. Schulze
  • Paolo Chiodini
  • Giovanna Masala
  • Valeria Pala
  • Carlotta Sacerdote
  • Rosario Tumino
  • Marije F. Bakker
  • Antonio Agudo
  • Eva Ardanaz
  • Maria Dolores Chirlaque Lopez
  • Maria-Jose Sanchez
  • Ulrika Ericson
  • Bjorn Gylling
  • Therese Karlsson
  • Jonas Manjer
  • Julie A. Schmidt
  • Genevieve Nicolas
  • Corinne Casagrande
  • Elisabete Weiderpass
  • Alicia K. Heath
  • Lode Godderis
  • Koen Van Herck
  • Dirk De Bacquer
  • Marc J. Gunter
  • Inge Huybrechts

(1) Background: Methyl-group donors (MGDs), including folate, choline, betaine, and methionine, may influence breast cancer (BC) risk through their role in one-carbon metabolism; (2) Methods: We studied the relationship between dietary intakes of MGDs and BC risk, adopting data from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort; (3) Results: 318,686 pre- and postmenopausal women were followed between enrolment in 1992-2000 and December 2013-December 2015. Dietary MGD intakes were estimated at baseline through food-frequency questionnaires. Multivariable Cox proportional hazards regression models were used to quantify the association between dietary intake of MGDs, measured both as a calculated score based on their sum and individually, and BC risk. Subgroup analyses were performed by hormone receptor status, menopausal status, and level of alcohol intake. During a mean follow-up time of 14.1 years, 13,320 women with malignant BC were identified. No associations were found between dietary intakes of the MGD score or individual MGDs and BC risk. However, a potential U-shaped relationship was observed between dietary folate intake and overall BC risk, suggesting an inverse association for intakes up to 350 mu g/day compared to a reference intake of 205 mu g/day. No statistically significant differences in the associations were observed by hormone receptor status, menopausal status, or level of alcohol intake; (4) Conclusions: There was no strong evidence for an association between MGDs involved in one-carbon metabolism and BC risk. However, a potential U-shaped trend was suggested for dietary folate intake and BC risk. Further research is needed to clarify this association.

Udgave nummer6
Antal sider15
StatusUdgivet - 2021

ID: 273531537