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Differences in cardiovascular risk profile between electrocardiographic hypertrophy versus strain in asymptomatic patients with aortic stenosis (from SEAS data)

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

  • Anders M Greve
  • Eva Gerdts
  • Kurt Boman
  • Christa Gohlke-Baerwolf
  • Anne B Rossebø
  • Sophia Hammer-Hansen
  • Køber, Lars Valeur
  • Ronnie Willenheimer
  • Kristian Wachtell
Electrocardiograms are routinely obtained in clinical follow-up of patients with asymptomatic aortic stenosis (AS). The association with aortic valve, left ventricular (LV) response to long-term pressure load, and clinical covariates is unclear and the clinical value is thus uncertain. Data from clinical examination, electrocardiogram, and echocardiogram in 1,563 patients in the Simvastatin and Ezetimibe in Aortic Stenosis (SEAS) study were used. Electrocardiograms were Minnesota coded for arrhythmias and atrioventricular and intraventricular blocks; LV hypertrophy was assessed by Sokolow-Lyon voltage and Cornell voltage-duration criteria; and strain by T-wave inversion and ST-segment depression. Degree of AS severity was evaluated by echocardiography as peak aortic jet velocity and LV mass was indexed by body surface area. After adjustment for age, gender, LV mass index, heart rate, systolic and diastolic blood pressures, blood glucose, digoxin, antiarrhythmic drugs, drugs acting on the renin-angiotensin system, diuretics, ß blockers and calcium receptor blockers; peak aortic jet velocity was significantly greater in patients with electrocardiographic strain (mean difference 0.13 m/s, p
OriginalsprogEngelsk
TidsskriftAmerican Journal of Cardiology
Vol/bind108
Udgave nummer4
Sider (fra-til)541-7
Antal sider7
ISSN0002-9149
DOI
StatusUdgivet - 2011

ID: 40173498