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Differential islet and incretin hormone responses in morning versus afternoon after standardized meal in healthy men

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Standard

Differential islet and incretin hormone responses in morning versus afternoon after standardized meal in healthy men. / Lindgren, Ola; Mari, Andrea; Deacon, Carolyn F; Carr, Richard D; Winzell, Maria Sörhede; Vikman, Jenny; Ahrén, Bo.

I: Journal of Clinical Endocrinology and Metabolism, Bind 94, Nr. 8, 2009, s. 2887-92.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Lindgren, O, Mari, A, Deacon, CF, Carr, RD, Winzell, MS, Vikman, J & Ahrén, B 2009, 'Differential islet and incretin hormone responses in morning versus afternoon after standardized meal in healthy men', Journal of Clinical Endocrinology and Metabolism, bind 94, nr. 8, s. 2887-92. https://doi.org/10.1210/jc.2009-0366

APA

Lindgren, O., Mari, A., Deacon, C. F., Carr, R. D., Winzell, M. S., Vikman, J., & Ahrén, B. (2009). Differential islet and incretin hormone responses in morning versus afternoon after standardized meal in healthy men. Journal of Clinical Endocrinology and Metabolism, 94(8), 2887-92. https://doi.org/10.1210/jc.2009-0366

Vancouver

Lindgren O, Mari A, Deacon CF, Carr RD, Winzell MS, Vikman J o.a. Differential islet and incretin hormone responses in morning versus afternoon after standardized meal in healthy men. Journal of Clinical Endocrinology and Metabolism. 2009;94(8):2887-92. https://doi.org/10.1210/jc.2009-0366

Author

Lindgren, Ola ; Mari, Andrea ; Deacon, Carolyn F ; Carr, Richard D ; Winzell, Maria Sörhede ; Vikman, Jenny ; Ahrén, Bo. / Differential islet and incretin hormone responses in morning versus afternoon after standardized meal in healthy men. I: Journal of Clinical Endocrinology and Metabolism. 2009 ; Bind 94, Nr. 8. s. 2887-92.

Bibtex

@article{27509ed0334111df8ed1000ea68e967b,
title = "Differential islet and incretin hormone responses in morning versus afternoon after standardized meal in healthy men",
abstract = "CONTEXT: The insulin response to meal ingestion is more rapid in the morning than in the afternoon. Whether this is explained by a corresponding variation in the incretin hormones is not known. OBJECTIVE: Our objective was to assess islet and incretin hormones after meal ingestion in the morning vs. afternoon. DESIGN, SETTINGS, AND PARTICIPANTS: Ingestion at 0800 and 1700 h of a standardized meal (524 kcal) in healthy lean males (n = 12) at a University Clinical Research Unit. MAIN OUTCOME MEASURES: We assessed early (30-min) area under the curve (AUC30) of plasma levels of insulin and intact (i) and total (t) glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) after meal ingestion and made an estimation of beta-cell function by model analysis of glucose and C-peptide. RESULTS: Peak glucose was lower in the morning than in the afternoon (6.1 +/- 0.2 vs. 7.4 +/- 0.3 mmol/liter, P = 0.001). AUC30(insulin) (4.9 +/- 0.6 vs. 2.8 +/- 0.4 nmol/liter . 30 min; P = 0.012), AUC30(tGLP-1) (300 +/- 40 vs. 160 +/- 30 pmol/liter . 30 min, P = 0.002), AUC30(iGIP) (0.7 +/- 0.1 vs. 0.3 +/- 0.1 nmol/liter . 30 min, P = 0.002), and AUC30(tGIP) (1.1 +/- 0.1 vs. 0.6 +/- 0.1 nmol/liter . min, P = 0.007) were all higher in the morning. AUC30(iGLP-1) (r = 0.68; P = 0.021) and AUC30(iGIP) (r = 0.78; P = 0.001) both correlated to AUC30(insulin). Model analysis of beta-cell function showed a higher first-hour potentiation factor in the morning (P = 0.009). This correlated negatively with the 60-min glucose level (r = -0.63; P < 0.001). CONCLUSIONS: The early release of GLP-1 and GIP are more pronounced in the morning than in the afternoon. This may contribute to the more rapid early insulin response, more pronounced potentiation of beta-cell function, and lower glucose after the morning meal.",
author = "Ola Lindgren and Andrea Mari and Deacon, {Carolyn F} and Carr, {Richard D} and Winzell, {Maria S{\"o}rhede} and Jenny Vikman and Bo Ahr{\'e}n",
note = "Keywords: Adult; Blood Glucose; C-Peptide; Fatty Acids, Nonesterified; Gastric Inhibitory Polypeptide; Glucagon; Humans; Incretins; Insulin; Islets of Langerhans; Male; Postprandial Period; Time Factors",
year = "2009",
doi = "10.1210/jc.2009-0366",
language = "English",
volume = "94",
pages = "2887--92",
journal = "Journal of Clinical Endocrinology and Metabolism",
issn = "0021-972X",
publisher = "Oxford University Press",
number = "8",

}

RIS

TY - JOUR

T1 - Differential islet and incretin hormone responses in morning versus afternoon after standardized meal in healthy men

AU - Lindgren, Ola

AU - Mari, Andrea

AU - Deacon, Carolyn F

AU - Carr, Richard D

AU - Winzell, Maria Sörhede

AU - Vikman, Jenny

AU - Ahrén, Bo

N1 - Keywords: Adult; Blood Glucose; C-Peptide; Fatty Acids, Nonesterified; Gastric Inhibitory Polypeptide; Glucagon; Humans; Incretins; Insulin; Islets of Langerhans; Male; Postprandial Period; Time Factors

PY - 2009

Y1 - 2009

N2 - CONTEXT: The insulin response to meal ingestion is more rapid in the morning than in the afternoon. Whether this is explained by a corresponding variation in the incretin hormones is not known. OBJECTIVE: Our objective was to assess islet and incretin hormones after meal ingestion in the morning vs. afternoon. DESIGN, SETTINGS, AND PARTICIPANTS: Ingestion at 0800 and 1700 h of a standardized meal (524 kcal) in healthy lean males (n = 12) at a University Clinical Research Unit. MAIN OUTCOME MEASURES: We assessed early (30-min) area under the curve (AUC30) of plasma levels of insulin and intact (i) and total (t) glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) after meal ingestion and made an estimation of beta-cell function by model analysis of glucose and C-peptide. RESULTS: Peak glucose was lower in the morning than in the afternoon (6.1 +/- 0.2 vs. 7.4 +/- 0.3 mmol/liter, P = 0.001). AUC30(insulin) (4.9 +/- 0.6 vs. 2.8 +/- 0.4 nmol/liter . 30 min; P = 0.012), AUC30(tGLP-1) (300 +/- 40 vs. 160 +/- 30 pmol/liter . 30 min, P = 0.002), AUC30(iGIP) (0.7 +/- 0.1 vs. 0.3 +/- 0.1 nmol/liter . 30 min, P = 0.002), and AUC30(tGIP) (1.1 +/- 0.1 vs. 0.6 +/- 0.1 nmol/liter . min, P = 0.007) were all higher in the morning. AUC30(iGLP-1) (r = 0.68; P = 0.021) and AUC30(iGIP) (r = 0.78; P = 0.001) both correlated to AUC30(insulin). Model analysis of beta-cell function showed a higher first-hour potentiation factor in the morning (P = 0.009). This correlated negatively with the 60-min glucose level (r = -0.63; P < 0.001). CONCLUSIONS: The early release of GLP-1 and GIP are more pronounced in the morning than in the afternoon. This may contribute to the more rapid early insulin response, more pronounced potentiation of beta-cell function, and lower glucose after the morning meal.

AB - CONTEXT: The insulin response to meal ingestion is more rapid in the morning than in the afternoon. Whether this is explained by a corresponding variation in the incretin hormones is not known. OBJECTIVE: Our objective was to assess islet and incretin hormones after meal ingestion in the morning vs. afternoon. DESIGN, SETTINGS, AND PARTICIPANTS: Ingestion at 0800 and 1700 h of a standardized meal (524 kcal) in healthy lean males (n = 12) at a University Clinical Research Unit. MAIN OUTCOME MEASURES: We assessed early (30-min) area under the curve (AUC30) of plasma levels of insulin and intact (i) and total (t) glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) after meal ingestion and made an estimation of beta-cell function by model analysis of glucose and C-peptide. RESULTS: Peak glucose was lower in the morning than in the afternoon (6.1 +/- 0.2 vs. 7.4 +/- 0.3 mmol/liter, P = 0.001). AUC30(insulin) (4.9 +/- 0.6 vs. 2.8 +/- 0.4 nmol/liter . 30 min; P = 0.012), AUC30(tGLP-1) (300 +/- 40 vs. 160 +/- 30 pmol/liter . 30 min, P = 0.002), AUC30(iGIP) (0.7 +/- 0.1 vs. 0.3 +/- 0.1 nmol/liter . 30 min, P = 0.002), and AUC30(tGIP) (1.1 +/- 0.1 vs. 0.6 +/- 0.1 nmol/liter . min, P = 0.007) were all higher in the morning. AUC30(iGLP-1) (r = 0.68; P = 0.021) and AUC30(iGIP) (r = 0.78; P = 0.001) both correlated to AUC30(insulin). Model analysis of beta-cell function showed a higher first-hour potentiation factor in the morning (P = 0.009). This correlated negatively with the 60-min glucose level (r = -0.63; P < 0.001). CONCLUSIONS: The early release of GLP-1 and GIP are more pronounced in the morning than in the afternoon. This may contribute to the more rapid early insulin response, more pronounced potentiation of beta-cell function, and lower glucose after the morning meal.

U2 - 10.1210/jc.2009-0366

DO - 10.1210/jc.2009-0366

M3 - Journal article

C2 - 19435824

VL - 94

SP - 2887

EP - 2892

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

SN - 0021-972X

IS - 8

ER -

ID: 18699471