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Discovery of potent and selective agonists for the free fatty acid receptor 1 (FFA(1)/GPR40), a potential target for the treatment of type II diabetes

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A series of 4-phenethynyldihydrocinnamic acid agonists of the free fatty acid receptor 1 (FFA(1)) has been discovered and explored. The preferred compound 20 (TUG-424, EC(50) = 32 nM) significantly increased glucose-stimulated insulin secretion at 100 nM and may serve to explore the role of FFA(1) in metabolic diseases such as diabetes or obesity.
OriginalsprogEngelsk
TidsskriftJournal of Medicinal Chemistry
Vol/bind51
Udgave nummer22
Sider (fra-til)7061-4
Antal sider4
ISSN0022-2623
DOI
StatusUdgivet - 27 nov. 2008

ID: 46275205