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Discovery of potent and selective agonists for the free fatty acid receptor 1 (FFA(1)/GPR40), a potential target for the treatment of type II diabetes

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

  • Ulven, Elisabeth Rexen
  • Christian Urban
  • Nicole Merten
  • Kathrin Liebscher
  • Kasper Kannegård Karlsen
  • Alexandra Hamacher
  • Andreas Spinrath
  • Andrew D Bond
  • Christel Drewke
  • Susanne Ullrich
  • Matthias U Kassack
  • Evi Kostenis
  • Ulven, Trond
A series of 4-phenethynyldihydrocinnamic acid agonists of the free fatty acid receptor 1 (FFA(1)) has been discovered and explored. The preferred compound 20 (TUG-424, EC(50) = 32 nM) significantly increased glucose-stimulated insulin secretion at 100 nM and may serve to explore the role of FFA(1) in metabolic diseases such as diabetes or obesity.
OriginalsprogEngelsk
TidsskriftJournal of Medicinal Chemistry
Vol/bind51
Udgave nummer22
Sider (fra-til)7061-4
Antal sider4
ISSN0022-2623
DOI
StatusUdgivet - 27 nov. 2008

ID: 46275205