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Diuretic treatment in decompensated cirrhosis and congestive heart failure: effect of posture

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Standard

Diuretic treatment in decompensated cirrhosis and congestive heart failure: effect of posture. / Ring-Larsen, H; Henriksen, Jens Henrik Sahl; Wilken, C; Clausen, J; Pals, H; Christensen, N J.

I: British medical journal (Clinical research ed.), Bind 292, Nr. 6532, 1986, s. 1351-3.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Ring-Larsen, H, Henriksen, JHS, Wilken, C, Clausen, J, Pals, H & Christensen, NJ 1986, 'Diuretic treatment in decompensated cirrhosis and congestive heart failure: effect of posture', British medical journal (Clinical research ed.), bind 292, nr. 6532, s. 1351-3.

APA

Ring-Larsen, H., Henriksen, J. H. S., Wilken, C., Clausen, J., Pals, H., & Christensen, N. J. (1986). Diuretic treatment in decompensated cirrhosis and congestive heart failure: effect of posture. British medical journal (Clinical research ed.), 292(6532), 1351-3.

Vancouver

Ring-Larsen H, Henriksen JHS, Wilken C, Clausen J, Pals H, Christensen NJ. Diuretic treatment in decompensated cirrhosis and congestive heart failure: effect of posture. British medical journal (Clinical research ed.). 1986;292(6532):1351-3.

Author

Ring-Larsen, H ; Henriksen, Jens Henrik Sahl ; Wilken, C ; Clausen, J ; Pals, H ; Christensen, N J. / Diuretic treatment in decompensated cirrhosis and congestive heart failure: effect of posture. I: British medical journal (Clinical research ed.). 1986 ; Bind 292, Nr. 6532. s. 1351-3.

Bibtex

@article{9b10c14038ca11dfad7f000ea68e967b,
title = "Diuretic treatment in decompensated cirrhosis and congestive heart failure: effect of posture",
abstract = "The diuretic effect of the supine position was evaluated in six patients with cirrhosis and ascites and six with congestive cardiac failure. After fasting overnight in bed the patients received bumetanide 1 mg intravenously and were then immediately randomly assigned to either bed rest in the supine position or normal daily activity in the upright position for the next six hours. Two days later the procedure was repeated, the patients being assigned to the other posture. The diuretic response was similar in patients with heart failure and cirrhosis, and was significantly greater in the supine than in the upright position: mean 1133 v 626 ml/6 h (p less than 0.01). The natriuresis was similarly larger during recumbency: mean sodium 96 v 45 mmol(mEq)/6h (p less than 0.01), and the excreted potassium in six hours was similar in both postures. The glomerular filtration rate was 100 and 66 ml/min (p less than 0.01) and heart rate 76 and 83 beats/min (p less than 0.01) in the supine and upright positions respectively. Plasma concentrations of noradrenaline, renin, and aldosterone were all raised even when the patient adopted the supine position, and a further significant rise was observed during the upright position. The results suggest that the attenuated response to intravenous bumetanide in the upright position and during normal daily activity may be due to the activation of several homeostatic mechanisms that may reduce the excretion of water and salt.",
author = "H Ring-Larsen and Henriksen, {Jens Henrik Sahl} and C Wilken and J Clausen and H Pals and Christensen, {N J}",
note = "Keywords: Adult; Aged; Aldosterone; Bumetanide; Diuretics; Female; Glomerular Filtration Rate; Heart Failure; Heart Rate; Humans; Liver Cirrhosis; Male; Middle Aged; Norepinephrine; Posture; Potassium; Renin; Sodium",
year = "1986",
language = "English",
volume = "292",
pages = "1351--3",
journal = "British medical journal",
issn = "0007-1447",
publisher = "British Medical Association",
number = "6532",

}

RIS

TY - JOUR

T1 - Diuretic treatment in decompensated cirrhosis and congestive heart failure: effect of posture

AU - Ring-Larsen, H

AU - Henriksen, Jens Henrik Sahl

AU - Wilken, C

AU - Clausen, J

AU - Pals, H

AU - Christensen, N J

N1 - Keywords: Adult; Aged; Aldosterone; Bumetanide; Diuretics; Female; Glomerular Filtration Rate; Heart Failure; Heart Rate; Humans; Liver Cirrhosis; Male; Middle Aged; Norepinephrine; Posture; Potassium; Renin; Sodium

PY - 1986

Y1 - 1986

N2 - The diuretic effect of the supine position was evaluated in six patients with cirrhosis and ascites and six with congestive cardiac failure. After fasting overnight in bed the patients received bumetanide 1 mg intravenously and were then immediately randomly assigned to either bed rest in the supine position or normal daily activity in the upright position for the next six hours. Two days later the procedure was repeated, the patients being assigned to the other posture. The diuretic response was similar in patients with heart failure and cirrhosis, and was significantly greater in the supine than in the upright position: mean 1133 v 626 ml/6 h (p less than 0.01). The natriuresis was similarly larger during recumbency: mean sodium 96 v 45 mmol(mEq)/6h (p less than 0.01), and the excreted potassium in six hours was similar in both postures. The glomerular filtration rate was 100 and 66 ml/min (p less than 0.01) and heart rate 76 and 83 beats/min (p less than 0.01) in the supine and upright positions respectively. Plasma concentrations of noradrenaline, renin, and aldosterone were all raised even when the patient adopted the supine position, and a further significant rise was observed during the upright position. The results suggest that the attenuated response to intravenous bumetanide in the upright position and during normal daily activity may be due to the activation of several homeostatic mechanisms that may reduce the excretion of water and salt.

AB - The diuretic effect of the supine position was evaluated in six patients with cirrhosis and ascites and six with congestive cardiac failure. After fasting overnight in bed the patients received bumetanide 1 mg intravenously and were then immediately randomly assigned to either bed rest in the supine position or normal daily activity in the upright position for the next six hours. Two days later the procedure was repeated, the patients being assigned to the other posture. The diuretic response was similar in patients with heart failure and cirrhosis, and was significantly greater in the supine than in the upright position: mean 1133 v 626 ml/6 h (p less than 0.01). The natriuresis was similarly larger during recumbency: mean sodium 96 v 45 mmol(mEq)/6h (p less than 0.01), and the excreted potassium in six hours was similar in both postures. The glomerular filtration rate was 100 and 66 ml/min (p less than 0.01) and heart rate 76 and 83 beats/min (p less than 0.01) in the supine and upright positions respectively. Plasma concentrations of noradrenaline, renin, and aldosterone were all raised even when the patient adopted the supine position, and a further significant rise was observed during the upright position. The results suggest that the attenuated response to intravenous bumetanide in the upright position and during normal daily activity may be due to the activation of several homeostatic mechanisms that may reduce the excretion of water and salt.

M3 - Journal article

C2 - 3085844

VL - 292

SP - 1351

EP - 1353

JO - British medical journal

JF - British medical journal

SN - 0007-1447

IS - 6532

ER -

ID: 18838144