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Dopamine, dobutamine, and dopexamine. A comparison of renal effects in unanesthetized human volunteers

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  • Niels Vidiendal Olsen
  • J Lund
  • P F Jensen
  • K Espersen
  • I L Kanstrup
  • I Plum
  • Paul Peter Leyssac
Recently, dopexamine (DX), which acts via adrenergic beta 2 and dopaminergic DA1 receptors, has been introduced in the treatment of low cardiac output states. However, the renal effects of DX have not been compared to those produced by equipotent inotropic doses of dopamine (DA), which predominantly stimulates DA1 and DA2 receptors, and of dobutamine (DB), which stimulates beta 1 but not DA receptors. The current study tested the null hypothesis that, with equal increases in cardiac output, DX, DA, and DB would have similar effects on renal function.
OriginalsprogEngelsk
TidsskriftAnesthesiology
Vol/bind79
Udgave nummer4
Sider (fra-til)685-94
Antal sider10
ISSN0003-3022
StatusUdgivet - okt. 1993

ID: 47240829