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Double-blind trial of bestatin in HIV-positive patients

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Twenty-two HIV-positive homosexual men with a moderately impaired immune system were randomized to bestatin capsules 60 mg a day or placebo for 4 weeks. None suffered from opportunistic infections. The immunomodulating effect of bestatin was investigated by lymphocyte proliferation assay with pokeweed mitogen, phytohaemagglutinin, and concanavalin A, surface marker analysis of T-helper/T-suppressor cells by flow cytometry, natural killer cell activity, beta-2-microglobulin and HIV antibody quantitation. No significant differences between bestatin and placebo in immunological, haematological, biochemical or clinical variables were detected.
OriginalsprogEngelsk
TidsskriftBiomedicine & Pharmacotherapy
Vol/bind44
Udgave nummer9
Sider (fra-til)475-8
Antal sider4
ISSN0753-3322
StatusUdgivet - 1 jan. 1990

ID: 33891108