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Drug-induced hepatic injury: an analysis of 1100 cases reported to the Danish Committee on Adverse Drug Reactions between 1978 and 1987

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Standard

Drug-induced hepatic injury : an analysis of 1100 cases reported to the Danish Committee on Adverse Drug Reactions between 1978 and 1987. / Friis, Henrik; Andreasen, P B.

I: Journal of Internal Medicine, Bind 232, Nr. 2, 08.1992, s. 133-138.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Friis, H & Andreasen, PB 1992, 'Drug-induced hepatic injury: an analysis of 1100 cases reported to the Danish Committee on Adverse Drug Reactions between 1978 and 1987', Journal of Internal Medicine, bind 232, nr. 2, s. 133-138.

APA

Friis, H., & Andreasen, P. B. (1992). Drug-induced hepatic injury: an analysis of 1100 cases reported to the Danish Committee on Adverse Drug Reactions between 1978 and 1987. Journal of Internal Medicine, 232(2), 133-138.

Vancouver

Friis H, Andreasen PB. Drug-induced hepatic injury: an analysis of 1100 cases reported to the Danish Committee on Adverse Drug Reactions between 1978 and 1987. Journal of Internal Medicine. 1992 aug;232(2):133-138.

Author

Friis, Henrik ; Andreasen, P B. / Drug-induced hepatic injury : an analysis of 1100 cases reported to the Danish Committee on Adverse Drug Reactions between 1978 and 1987. I: Journal of Internal Medicine. 1992 ; Bind 232, Nr. 2. s. 133-138.

Bibtex

@article{f77e323c7da1464daeab54d63f2507a6,
title = "Drug-induced hepatic injury: an analysis of 1100 cases reported to the Danish Committee on Adverse Drug Reactions between 1978 and 1987",
abstract = "The Danish Committee on Adverse Drug Reactions received 1100 reports of suspected drug-induced hepatic injury during the decade 1978-1987. The causal relationship between drug and hepatic injury was classified as definite in 57 (5.2{\%}) reports, probable in 989 (89.9{\%}) reports, possible in 50 (4.5{\%}) reports and unclassifiable in four (0.4{\%}) reports. Hepatic injuries accounted for 5.9{\%} of all adverse drug reactions reported, and 14.7{\%} of the lethal adverse drug reactions. A total of 47.2{\%} were classified as acute cytotoxic, 16.2{\%} as acute cholestatic and 26.9{\%} as abnormal hepatic function. In 52 (4.7{\%}) cases the hepatic injury was lethal; only 14 (1.3{\%}) cases were chronic. Halothane accounted for 25{\%} of the cases. The incidence of halothane-induced hepatic injury is decreasing, and only one lethal case has been reported since 1981. Next to halothane, sulfasalazine was the drug most often suspected during the last 2 years of the decade. Based on consumption data, the incidence of hepatic injury due to sulindac was estimated to be 18-fold higher than that due to ibuprofen. Paracetamol was reported to induce acute cytotoxic as well as cholestatic reactions in non-alcoholic subjects taking therapeutic doses.",
keywords = "Adolescent, Adult, Aged, Aged, 80 and over, Alkaline Phosphatase, Child, Child, Preschool, Clinical Enzyme Tests, Denmark, Drug-Induced Liver Injury, Female, Humans, Infant, Liver Diseases, Liver Function Tests, Male, Middle Aged, Transaminases",
author = "Henrik Friis and Andreasen, {P B}",
year = "1992",
month = "8",
language = "English",
volume = "232",
pages = "133--138",
journal = "Acta Medica Scandinavica",
issn = "0955-7873",
publisher = "Wiley-Blackwell",
number = "2",

}

RIS

TY - JOUR

T1 - Drug-induced hepatic injury

T2 - an analysis of 1100 cases reported to the Danish Committee on Adverse Drug Reactions between 1978 and 1987

AU - Friis, Henrik

AU - Andreasen, P B

PY - 1992/8

Y1 - 1992/8

N2 - The Danish Committee on Adverse Drug Reactions received 1100 reports of suspected drug-induced hepatic injury during the decade 1978-1987. The causal relationship between drug and hepatic injury was classified as definite in 57 (5.2%) reports, probable in 989 (89.9%) reports, possible in 50 (4.5%) reports and unclassifiable in four (0.4%) reports. Hepatic injuries accounted for 5.9% of all adverse drug reactions reported, and 14.7% of the lethal adverse drug reactions. A total of 47.2% were classified as acute cytotoxic, 16.2% as acute cholestatic and 26.9% as abnormal hepatic function. In 52 (4.7%) cases the hepatic injury was lethal; only 14 (1.3%) cases were chronic. Halothane accounted for 25% of the cases. The incidence of halothane-induced hepatic injury is decreasing, and only one lethal case has been reported since 1981. Next to halothane, sulfasalazine was the drug most often suspected during the last 2 years of the decade. Based on consumption data, the incidence of hepatic injury due to sulindac was estimated to be 18-fold higher than that due to ibuprofen. Paracetamol was reported to induce acute cytotoxic as well as cholestatic reactions in non-alcoholic subjects taking therapeutic doses.

AB - The Danish Committee on Adverse Drug Reactions received 1100 reports of suspected drug-induced hepatic injury during the decade 1978-1987. The causal relationship between drug and hepatic injury was classified as definite in 57 (5.2%) reports, probable in 989 (89.9%) reports, possible in 50 (4.5%) reports and unclassifiable in four (0.4%) reports. Hepatic injuries accounted for 5.9% of all adverse drug reactions reported, and 14.7% of the lethal adverse drug reactions. A total of 47.2% were classified as acute cytotoxic, 16.2% as acute cholestatic and 26.9% as abnormal hepatic function. In 52 (4.7%) cases the hepatic injury was lethal; only 14 (1.3%) cases were chronic. Halothane accounted for 25% of the cases. The incidence of halothane-induced hepatic injury is decreasing, and only one lethal case has been reported since 1981. Next to halothane, sulfasalazine was the drug most often suspected during the last 2 years of the decade. Based on consumption data, the incidence of hepatic injury due to sulindac was estimated to be 18-fold higher than that due to ibuprofen. Paracetamol was reported to induce acute cytotoxic as well as cholestatic reactions in non-alcoholic subjects taking therapeutic doses.

KW - Adolescent

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Alkaline Phosphatase

KW - Child

KW - Child, Preschool

KW - Clinical Enzyme Tests

KW - Denmark

KW - Drug-Induced Liver Injury

KW - Female

KW - Humans

KW - Infant

KW - Liver Diseases

KW - Liver Function Tests

KW - Male

KW - Middle Aged

KW - Transaminases

M3 - Journal article

C2 - 1506809

VL - 232

SP - 133

EP - 138

JO - Acta Medica Scandinavica

JF - Acta Medica Scandinavica

SN - 0955-7873

IS - 2

ER -

ID: 119653605