Forskning ved Københavns Universitet - Københavns Universitet

Forside

Effect of electroconvulsive therapy on neural response to affective pictures: A randomized, sham-controlled fMRI study

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Standard

Effect of electroconvulsive therapy on neural response to affective pictures : A randomized, sham-controlled fMRI study. / Miskowiak, Kamilla Woznica; Macoveanu, Julian; Jørgensen, Merete Barker; Ott, Caroline Vintergaard; Støttrup, M M; Jensen, Hannah Malene; Jørgensen, A; Harmer, Catherine J; Paulson, Olaf B.; Siebner, Hartwig Roman; Kessing, Lars Vedel.

I: European Neuropsychopharmacology, Bind 28, Nr. 8, 08.2018, s. 915-924.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Miskowiak, KW, Macoveanu, J, Jørgensen, MB, Ott, CV, Støttrup, MM, Jensen, HM, Jørgensen, A, Harmer, CJ, Paulson, OB, Siebner, HR & Kessing, LV 2018, 'Effect of electroconvulsive therapy on neural response to affective pictures: A randomized, sham-controlled fMRI study', European Neuropsychopharmacology, bind 28, nr. 8, s. 915-924. https://doi.org/10.1016/j.euroneuro.2018.05.013

APA

Miskowiak, K. W., Macoveanu, J., Jørgensen, M. B., Ott, C. V., Støttrup, M. M., Jensen, H. M., ... Kessing, L. V. (2018). Effect of electroconvulsive therapy on neural response to affective pictures: A randomized, sham-controlled fMRI study. European Neuropsychopharmacology, 28(8), 915-924. https://doi.org/10.1016/j.euroneuro.2018.05.013

Vancouver

Miskowiak KW, Macoveanu J, Jørgensen MB, Ott CV, Støttrup MM, Jensen HM o.a. Effect of electroconvulsive therapy on neural response to affective pictures: A randomized, sham-controlled fMRI study. European Neuropsychopharmacology. 2018 aug;28(8):915-924. https://doi.org/10.1016/j.euroneuro.2018.05.013

Author

Miskowiak, Kamilla Woznica ; Macoveanu, Julian ; Jørgensen, Merete Barker ; Ott, Caroline Vintergaard ; Støttrup, M M ; Jensen, Hannah Malene ; Jørgensen, A ; Harmer, Catherine J ; Paulson, Olaf B. ; Siebner, Hartwig Roman ; Kessing, Lars Vedel. / Effect of electroconvulsive therapy on neural response to affective pictures : A randomized, sham-controlled fMRI study. I: European Neuropsychopharmacology. 2018 ; Bind 28, Nr. 8. s. 915-924.

Bibtex

@article{a223cb1488ec451aa245f0d12e35a49d,
title = "Effect of electroconvulsive therapy on neural response to affective pictures: A randomized, sham-controlled fMRI study",
abstract = "Electroconvulsive therapy (ECT) is the most effective treatment for severe depression but its neurocognitive mechanisms are unclear. This randomized, sham-controlled functional magnetic resonance imaging (fMRI) study explored the effects of a single ECT on neural response to affective pictures. Twenty-seven patients with major depressive disorder were randomized to a single active ECT (N = 15) or sham (N = 12) session in a double-blind, parallel-group design. On the following day, patients underwent fMRI during which they viewed pleasant, unpleasant and neutral pictures and performed a free recall test after the scan. Mood symptoms were assessed before ECT/sham and at the time of fMRI. Subsequently, all patients continued active ECT as usual. Mood symptoms were reassessed after six active ECT sessions. A single ECT vs. sham session reduced neural response to unpleasant vs. pleasant pictures in the medial prefrontal cortex, a region showing greater response in the more depressed patients. This effect occurred in the absence of between-group differences in picture recall, mood symptoms or concomitant medication. In conclusion, modulation of medial prefrontal hyper-activity during encoding of negative affective information may be a common mechanism of distinct biological depression treatments.",
keywords = "Depression, ECT, Magnetic resonance imaging, Neurocognition, Prefrontal cortex",
author = "Miskowiak, {Kamilla Woznica} and Julian Macoveanu and J{\o}rgensen, {Merete Barker} and Ott, {Caroline Vintergaard} and St{\o}ttrup, {M M} and Jensen, {Hannah Malene} and A J{\o}rgensen and Harmer, {Catherine J} and Paulson, {Olaf B.} and Siebner, {Hartwig Roman} and Kessing, {Lars Vedel}",
note = "Copyright {\circledC} 2018. Published by Elsevier B.V.",
year = "2018",
month = "8",
doi = "10.1016/j.euroneuro.2018.05.013",
language = "English",
volume = "28",
pages = "915--924",
journal = "European Neuropsychopharmacology",
issn = "0924-977X",
publisher = "Elsevier",
number = "8",

}

RIS

TY - JOUR

T1 - Effect of electroconvulsive therapy on neural response to affective pictures

T2 - A randomized, sham-controlled fMRI study

AU - Miskowiak, Kamilla Woznica

AU - Macoveanu, Julian

AU - Jørgensen, Merete Barker

AU - Ott, Caroline Vintergaard

AU - Støttrup, M M

AU - Jensen, Hannah Malene

AU - Jørgensen, A

AU - Harmer, Catherine J

AU - Paulson, Olaf B.

AU - Siebner, Hartwig Roman

AU - Kessing, Lars Vedel

N1 - Copyright © 2018. Published by Elsevier B.V.

PY - 2018/8

Y1 - 2018/8

N2 - Electroconvulsive therapy (ECT) is the most effective treatment for severe depression but its neurocognitive mechanisms are unclear. This randomized, sham-controlled functional magnetic resonance imaging (fMRI) study explored the effects of a single ECT on neural response to affective pictures. Twenty-seven patients with major depressive disorder were randomized to a single active ECT (N = 15) or sham (N = 12) session in a double-blind, parallel-group design. On the following day, patients underwent fMRI during which they viewed pleasant, unpleasant and neutral pictures and performed a free recall test after the scan. Mood symptoms were assessed before ECT/sham and at the time of fMRI. Subsequently, all patients continued active ECT as usual. Mood symptoms were reassessed after six active ECT sessions. A single ECT vs. sham session reduced neural response to unpleasant vs. pleasant pictures in the medial prefrontal cortex, a region showing greater response in the more depressed patients. This effect occurred in the absence of between-group differences in picture recall, mood symptoms or concomitant medication. In conclusion, modulation of medial prefrontal hyper-activity during encoding of negative affective information may be a common mechanism of distinct biological depression treatments.

AB - Electroconvulsive therapy (ECT) is the most effective treatment for severe depression but its neurocognitive mechanisms are unclear. This randomized, sham-controlled functional magnetic resonance imaging (fMRI) study explored the effects of a single ECT on neural response to affective pictures. Twenty-seven patients with major depressive disorder were randomized to a single active ECT (N = 15) or sham (N = 12) session in a double-blind, parallel-group design. On the following day, patients underwent fMRI during which they viewed pleasant, unpleasant and neutral pictures and performed a free recall test after the scan. Mood symptoms were assessed before ECT/sham and at the time of fMRI. Subsequently, all patients continued active ECT as usual. Mood symptoms were reassessed after six active ECT sessions. A single ECT vs. sham session reduced neural response to unpleasant vs. pleasant pictures in the medial prefrontal cortex, a region showing greater response in the more depressed patients. This effect occurred in the absence of between-group differences in picture recall, mood symptoms or concomitant medication. In conclusion, modulation of medial prefrontal hyper-activity during encoding of negative affective information may be a common mechanism of distinct biological depression treatments.

KW - Depression

KW - ECT

KW - Magnetic resonance imaging

KW - Neurocognition

KW - Prefrontal cortex

U2 - 10.1016/j.euroneuro.2018.05.013

DO - 10.1016/j.euroneuro.2018.05.013

M3 - Journal article

C2 - 29891215

VL - 28

SP - 915

EP - 924

JO - European Neuropsychopharmacology

JF - European Neuropsychopharmacology

SN - 0924-977X

IS - 8

ER -

ID: 203247426