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Effect of high doses of L-ascorbic acid on the antioxidative/oxidative state in the rats

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The objective of this study was to determine the effects of mega-doses of vitamin C (0.3, 0.6 and 0.9% of diet) as a dietary supplement for rats on selected indices of the antioxidative/oxidative state in 40 growing Wistar rats (4x10). It was found that L-ascorbic acid and Total Antioxidative State (TAS) in plasma did not increase with increasing vitamin C supply. The results indicate that high doses of L-ascorbic acid (0.3 and 0.9 but not 0.6%) increased the concentration of this antioxidant in plasma. Supplementation of vitamin C above 0.3% to the diets had pro-oxidative effects on lipid structures, while application of 0.9% promoted oxidative degradation of rat livers.
OriginalsprogEngelsk
TidsskriftJournal of Animal and Feed Sciences
Vol/bind14
Udgave nummerSuppl.1
Sider (fra-til)553-556
Antal sider4
ISSN1230-1388
StatusUdgivet - 2005

ID: 8000569