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Effect of oral proguanil on human lymphocyte proliferation

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Standard

Effect of oral proguanil on human lymphocyte proliferation. / Bygbjerg, Ib Christian; Flachs, H.

I: European Journal of Clinical Pharmacology, Bind 30, Nr. 2, 01.01.1986, s. 249-51.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Bygbjerg, IC & Flachs, H 1986, 'Effect of oral proguanil on human lymphocyte proliferation', European Journal of Clinical Pharmacology, bind 30, nr. 2, s. 249-51.

APA

Bygbjerg, I. C., & Flachs, H. (1986). Effect of oral proguanil on human lymphocyte proliferation. European Journal of Clinical Pharmacology, 30(2), 249-51.

Vancouver

Bygbjerg IC, Flachs H. Effect of oral proguanil on human lymphocyte proliferation. European Journal of Clinical Pharmacology. 1986 jan 1;30(2):249-51.

Author

Bygbjerg, Ib Christian ; Flachs, H. / Effect of oral proguanil on human lymphocyte proliferation. I: European Journal of Clinical Pharmacology. 1986 ; Bind 30, Nr. 2. s. 249-51.

Bibtex

@article{660e297484bd43f0b28196e9c5464bb4,
title = "Effect of oral proguanil on human lymphocyte proliferation",
abstract = "In vitro studies have indicated that the antifolates pyrimethamine [4, 6] and cycloguanil (the active metabolite of proguanil) suppress the proliferation of stimulated human lymphocytes; proguanil has no effect [2]. During the early growth phase of the cells, 14C-thymidine (14C-TdR) incorporation is increased by pyrimethamine and cycloguanil, reflecting blockage of endogenous TdR synthesis [3]. Proguanil (Paludrine) is increasingly being used for malaria prophylaxis. It is considered the most innocuous of the antimalarials currently employed. Since nothing is known about the effect of oral proguanil on human lymphocytes, the present study was undertaken. Little information is available about the serum levels of proguanil and cycloguanil following ingestion of prophylactic doses [8]. Therefore, the serum concentrations of proguanil and cycloguanil were estimated, to allow comparison with previous in vitro studies [2].",
keywords = "Adult, Humans, Leukocyte Count, Leukocytes, Lymphocyte Activation, Lymphocytes, Phytohemagglutinins, Proguanil, Pyrimethamine, Thymidine, Time Factors, Triazines",
author = "Bygbjerg, {Ib Christian} and H Flachs",
year = "1986",
month = "1",
day = "1",
language = "English",
volume = "30",
pages = "249--51",
journal = "European Journal of Clinical Pharmacology",
issn = "0031-6970",
publisher = "Springer",
number = "2",

}

RIS

TY - JOUR

T1 - Effect of oral proguanil on human lymphocyte proliferation

AU - Bygbjerg, Ib Christian

AU - Flachs, H

PY - 1986/1/1

Y1 - 1986/1/1

N2 - In vitro studies have indicated that the antifolates pyrimethamine [4, 6] and cycloguanil (the active metabolite of proguanil) suppress the proliferation of stimulated human lymphocytes; proguanil has no effect [2]. During the early growth phase of the cells, 14C-thymidine (14C-TdR) incorporation is increased by pyrimethamine and cycloguanil, reflecting blockage of endogenous TdR synthesis [3]. Proguanil (Paludrine) is increasingly being used for malaria prophylaxis. It is considered the most innocuous of the antimalarials currently employed. Since nothing is known about the effect of oral proguanil on human lymphocytes, the present study was undertaken. Little information is available about the serum levels of proguanil and cycloguanil following ingestion of prophylactic doses [8]. Therefore, the serum concentrations of proguanil and cycloguanil were estimated, to allow comparison with previous in vitro studies [2].

AB - In vitro studies have indicated that the antifolates pyrimethamine [4, 6] and cycloguanil (the active metabolite of proguanil) suppress the proliferation of stimulated human lymphocytes; proguanil has no effect [2]. During the early growth phase of the cells, 14C-thymidine (14C-TdR) incorporation is increased by pyrimethamine and cycloguanil, reflecting blockage of endogenous TdR synthesis [3]. Proguanil (Paludrine) is increasingly being used for malaria prophylaxis. It is considered the most innocuous of the antimalarials currently employed. Since nothing is known about the effect of oral proguanil on human lymphocytes, the present study was undertaken. Little information is available about the serum levels of proguanil and cycloguanil following ingestion of prophylactic doses [8]. Therefore, the serum concentrations of proguanil and cycloguanil were estimated, to allow comparison with previous in vitro studies [2].

KW - Adult

KW - Humans

KW - Leukocyte Count

KW - Leukocytes

KW - Lymphocyte Activation

KW - Lymphocytes

KW - Phytohemagglutinins

KW - Proguanil

KW - Pyrimethamine

KW - Thymidine

KW - Time Factors

KW - Triazines

M3 - Journal article

C2 - 3709655

VL - 30

SP - 249

EP - 251

JO - European Journal of Clinical Pharmacology

JF - European Journal of Clinical Pharmacology

SN - 0031-6970

IS - 2

ER -

ID: 33891791