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Effect of sex in the MRMT-1 model of cancer-induced bone pain

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An overwhelming amount of evidence demonstrates sex-induced variation in pain processing, and has thus increased the focus on sex as an essential parameter for optimization of in vivo models in pain research. Mammary cancer cells are often used to model metastatic bone pain in vivo, and are commonly used in both males and females. Here we demonstrate that compared to male rats, female rats have an increased capacity for recovery following inoculation of MRMT-1 mammary cells, thus potentially causing a sex-dependent bias in interpretation of the data.
OriginalsprogEngelsk
Artikelnummer445
TidsskriftF1000Research
Vol/bind4
Udgave nummer445
Sider (fra-til)1-18
Antal sider18
ISSN2046-1402
DOI
StatusUdgivet - 2015

Bibliografisk note

CURIS 2015 NEXS 426

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