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Effect of trefoil factors on the viscoelastic properties of mucus gels

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Trefoil peptides (TFFs) are expressed and secreted in a tissue-specific manner in the gastrointestinal tract. Evidence of coexpression of trefoil peptides and mucins has been demonstrated in most mucus-producing cells in the gastrointestinal tract. The expression of trefoil peptides is up-regulated in gastric ulceration and colitis. It is believed that TFF peptides interact with mucin to increase viscosity but this has never been confirmed. The aims of the present study were to elucidate the direct effect of trefoil peptides on mucus gel formation.
OriginalsprogEngelsk
TidsskriftEuropean Journal of Clinical Investigation
Vol/bind32
Udgave nummer7
Sider (fra-til)519-27
Antal sider9
ISSN0014-2972
StatusUdgivet - 1 jul. 2002

ID: 33793046