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Effects of exercise training on mitochondrial function in patients with type 2 diabetes

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Standard

Effects of exercise training on mitochondrial function in patients with type 2 diabetes. / Larsen, Steen; Skaaby, Stinna; Helge, Jørn Wulff; Dela, Flemming.

I: World Journal of Diabetes, Bind 5, Nr. 4, 15.08.2014, s. 482-92.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Larsen, S, Skaaby, S, Helge, JW & Dela, F 2014, 'Effects of exercise training on mitochondrial function in patients with type 2 diabetes', World Journal of Diabetes, bind 5, nr. 4, s. 482-92. https://doi.org/10.4239/wjd.v5.i4.482

APA

Larsen, S., Skaaby, S., Helge, J. W., & Dela, F. (2014). Effects of exercise training on mitochondrial function in patients with type 2 diabetes. World Journal of Diabetes, 5(4), 482-92. https://doi.org/10.4239/wjd.v5.i4.482

Vancouver

Larsen S, Skaaby S, Helge JW, Dela F. Effects of exercise training on mitochondrial function in patients with type 2 diabetes. World Journal of Diabetes. 2014 aug 15;5(4):482-92. https://doi.org/10.4239/wjd.v5.i4.482

Author

Larsen, Steen ; Skaaby, Stinna ; Helge, Jørn Wulff ; Dela, Flemming. / Effects of exercise training on mitochondrial function in patients with type 2 diabetes. I: World Journal of Diabetes. 2014 ; Bind 5, Nr. 4. s. 482-92.

Bibtex

@article{c4cf9e50543541d7a1e615c4bf04ada0,
title = "Effects of exercise training on mitochondrial function in patients with type 2 diabetes",
abstract = "Type 2 diabetes is characterized by a decreased ability of insulin to facilitate glucose uptake into insulin sensitive tissue, i.e., skeletal muscle. The mechanism behind this is at the moment unresolved. It has been suggested that increased amount of lipids inside the skeletal muscle (intramuscular triglyceride, diacylglycerol and ceramides) will impair insulin action in skeletal muscle, but data are not consistent in the human literature. It has also been hypothesized that the impaired insulin sensitivity is due to a dysfunction in the mitochondria resulting in an impaired ability to oxidize lipids, but the majority of the literature is not supporting this hypothesis. Recently it has been suggested that the production of reactive oxygen species play an essential role in skeletal muscle insulin sensitivity. It is well accepted that physical activity (endurance, strength and high intensity training) improves insulin sensitivity in healthy humans and in patients with type 2 diabetes. Whether patients with type 2 diabetes have the same beneficial effects (same improvement) as control subjects, when it comes to regular physical activity in regard to mitochondrial function, is not established in the literature. This review will focus only on the effect of physical activity on skeletal muscle (mitochondrial function) in patients with type 2 diabetes.",
author = "Steen Larsen and Stinna Skaaby and Helge, {J{\o}rn Wulff} and Flemming Dela",
year = "2014",
month = "8",
day = "15",
doi = "10.4239/wjd.v5.i4.482",
language = "English",
volume = "5",
pages = "482--92",
journal = "World Journal of Diabetes",
issn = "1948-9358",
publisher = "Baishideng Publishing Group Co., Limited",
number = "4",

}

RIS

TY - JOUR

T1 - Effects of exercise training on mitochondrial function in patients with type 2 diabetes

AU - Larsen, Steen

AU - Skaaby, Stinna

AU - Helge, Jørn Wulff

AU - Dela, Flemming

PY - 2014/8/15

Y1 - 2014/8/15

N2 - Type 2 diabetes is characterized by a decreased ability of insulin to facilitate glucose uptake into insulin sensitive tissue, i.e., skeletal muscle. The mechanism behind this is at the moment unresolved. It has been suggested that increased amount of lipids inside the skeletal muscle (intramuscular triglyceride, diacylglycerol and ceramides) will impair insulin action in skeletal muscle, but data are not consistent in the human literature. It has also been hypothesized that the impaired insulin sensitivity is due to a dysfunction in the mitochondria resulting in an impaired ability to oxidize lipids, but the majority of the literature is not supporting this hypothesis. Recently it has been suggested that the production of reactive oxygen species play an essential role in skeletal muscle insulin sensitivity. It is well accepted that physical activity (endurance, strength and high intensity training) improves insulin sensitivity in healthy humans and in patients with type 2 diabetes. Whether patients with type 2 diabetes have the same beneficial effects (same improvement) as control subjects, when it comes to regular physical activity in regard to mitochondrial function, is not established in the literature. This review will focus only on the effect of physical activity on skeletal muscle (mitochondrial function) in patients with type 2 diabetes.

AB - Type 2 diabetes is characterized by a decreased ability of insulin to facilitate glucose uptake into insulin sensitive tissue, i.e., skeletal muscle. The mechanism behind this is at the moment unresolved. It has been suggested that increased amount of lipids inside the skeletal muscle (intramuscular triglyceride, diacylglycerol and ceramides) will impair insulin action in skeletal muscle, but data are not consistent in the human literature. It has also been hypothesized that the impaired insulin sensitivity is due to a dysfunction in the mitochondria resulting in an impaired ability to oxidize lipids, but the majority of the literature is not supporting this hypothesis. Recently it has been suggested that the production of reactive oxygen species play an essential role in skeletal muscle insulin sensitivity. It is well accepted that physical activity (endurance, strength and high intensity training) improves insulin sensitivity in healthy humans and in patients with type 2 diabetes. Whether patients with type 2 diabetes have the same beneficial effects (same improvement) as control subjects, when it comes to regular physical activity in regard to mitochondrial function, is not established in the literature. This review will focus only on the effect of physical activity on skeletal muscle (mitochondrial function) in patients with type 2 diabetes.

U2 - 10.4239/wjd.v5.i4.482

DO - 10.4239/wjd.v5.i4.482

M3 - Journal article

C2 - 25126394

VL - 5

SP - 482

EP - 492

JO - World Journal of Diabetes

JF - World Journal of Diabetes

SN - 1948-9358

IS - 4

ER -

ID: 132011409