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Effects of the immunomodulator, VGX-1027, in endotoxin-induced uveitis in Lewis rats

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

  • K Mangano
  • N Y Sardesai
  • C Quattrocchi
  • E Mazzon
  • S Cuzzocrea
  • K Bendtzen
  • P L Meroni
  • J J Kim
  • F Nicoletti
VGX-1027 is a novel, low molecular weight, immunomodulatory compound that has shown efficacy against a variety of immuno-inflammatory disease models in animals including autoimmune diabetes in NOD mice, collagen-induced arthritis and chemically induced inflammatory colitis. Here, we have studied the effects of VGX-1027 on the development of endotoxin-induced uveitis (EIU) in male Lewis rats, as a model of inflammatory ocular diseases in humans.
OriginalsprogEngelsk
TidsskriftBritish Journal of Pharmacology
Vol/bind155
Udgave nummer5
Sider (fra-til)722-30
Antal sider9
ISSN0007-1188
DOI
StatusUdgivet - 1 nov. 2008

ID: 34102673