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Efficient cell culture system for hepatitis C virus genotype 2B: Patent #: 8,663,653

Publikation: Patent

The present inventors developed hepatitis C virus 2b/2a intergenotypic recombinants in which the JFH1 structural genes (Core, E1 and E2), p7 and the complete NS2 were replaced by the corresponding genes of the genotype 2b reference strain J8. Sequence analysis of recovered 2b/2a recombinants from 2 transfection experiments revealed that 2b/2a was genetically stable. Conclusion: The developed 2b/2a viruses provide a robust in vitro tool for research in HCV genotype 2b, including vaccine studies and functional analysis.
OriginalsprogEngelsk
IPCA61K 39/12 (20060101); A61K 39/29 (20060101); C12N 1/20 (20060101); C12N 5/071 (20100101); C12N 15/00 (20060101); C12Q 1/70 (20060101)
PatentnummerWO2010/017818
Journaliseringsdato18/02/2010
Land/OmrådeDanmark
Prioritetsdato24/07/2009
PrioritetsnummerPCT/DK2009/050189
StatusUdgivet - 31 mar. 2014

ID: 140392319