Forskning ved Københavns Universitet - Københavns Universitet

Forside

Elucidating the role of interleukin-17F in cutaneous T-cell lymphoma

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Standard

Elucidating the role of interleukin-17F in cutaneous T-cell lymphoma. / Krejsgaard, Thorbjørn; Litvinov, Ivan V; Wang, Yang; Xia, Lixin; Willerslev-Olsen, Andreas; Koralov, Sergei B; Kopp, Katharina L; Bonefeld, Charlotte M; Wasik, Mariusz A; Geisler, Carsten; Woetmann, Anders; Zhou, Youwen; Sasseville, Denis; Odum, Niels.

I: Blood (online), Bind 122, Nr. 6, 25.06.2013, s. 943-950.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Krejsgaard, T, Litvinov, IV, Wang, Y, Xia, L, Willerslev-Olsen, A, Koralov, SB, Kopp, KL, Bonefeld, CM, Wasik, MA, Geisler, C, Woetmann, A, Zhou, Y, Sasseville, D & Odum, N 2013, 'Elucidating the role of interleukin-17F in cutaneous T-cell lymphoma', Blood (online), bind 122, nr. 6, s. 943-950. https://doi.org/10.1182/blood-2013-01-480889

APA

Krejsgaard, T., Litvinov, I. V., Wang, Y., Xia, L., Willerslev-Olsen, A., Koralov, S. B., ... Odum, N. (2013). Elucidating the role of interleukin-17F in cutaneous T-cell lymphoma. Blood (online), 122(6), 943-950. https://doi.org/10.1182/blood-2013-01-480889

Vancouver

Krejsgaard T, Litvinov IV, Wang Y, Xia L, Willerslev-Olsen A, Koralov SB o.a. Elucidating the role of interleukin-17F in cutaneous T-cell lymphoma. Blood (online). 2013 jun 25;122(6):943-950. https://doi.org/10.1182/blood-2013-01-480889

Author

Krejsgaard, Thorbjørn ; Litvinov, Ivan V ; Wang, Yang ; Xia, Lixin ; Willerslev-Olsen, Andreas ; Koralov, Sergei B ; Kopp, Katharina L ; Bonefeld, Charlotte M ; Wasik, Mariusz A ; Geisler, Carsten ; Woetmann, Anders ; Zhou, Youwen ; Sasseville, Denis ; Odum, Niels. / Elucidating the role of interleukin-17F in cutaneous T-cell lymphoma. I: Blood (online). 2013 ; Bind 122, Nr. 6. s. 943-950.

Bibtex

@article{7b4fc509d16a421b814e7a453b02aa2d,
title = "Elucidating the role of interleukin-17F in cutaneous T-cell lymphoma",
abstract = "Inappropriately regulated expression of IL-17A is associated with the development of inflammatory diseases and cancer. However, little is known about the role of other IL-17 family members in carcinogenesis. Here, we show that a set of malignant T-cell lines established from patients with cutaneous T-cell lymphoma (CTCL) spontaneously secrete IL-17F and that inhibitors of Jak and Stat3 are able to block that secretion. Other malignant T-cell lines produce IL-17A but not IL-17F. Upon activation, however, some of the malignant T-cell lines are able to co-express IL-17A and IL-17F leading to formation of IL-17A/F heterodimers. Clinically, we demonstrate that IL-17F mRNA expression is significantly increased in CTCL skin lesions when compared to healthy donors and patients with chronic dermatitis. IL-17A expression is also increased and a significant number of patients express high levels of both IL-17A and IL-17F. Concomitantly, we observe that the expression of the IL-17 receptor is significantly increased in CTCL skin lesions when compared to control subjects. Importantly, analysis of a historic cohort of 60 CTCL patients indicates that IL-17F expression is associated with progressive disease. These findings implicate IL-17F in the pathogenesis of CTCL and suggest that IL-17 cytokines and their receptors may serve as therapeutic targets.",
author = "Thorbj{\o}rn Krejsgaard and Litvinov, {Ivan V} and Yang Wang and Lixin Xia and Andreas Willerslev-Olsen and Koralov, {Sergei B} and Kopp, {Katharina L} and Bonefeld, {Charlotte M} and Wasik, {Mariusz A} and Carsten Geisler and Anders Woetmann and Youwen Zhou and Denis Sasseville and Niels Odum",
year = "2013",
month = "6",
day = "25",
doi = "10.1182/blood-2013-01-480889",
language = "English",
volume = "122",
pages = "943--950",
journal = "Blood",
issn = "0006-4971",
publisher = "American Society of Hematology",
number = "6",

}

RIS

TY - JOUR

T1 - Elucidating the role of interleukin-17F in cutaneous T-cell lymphoma

AU - Krejsgaard, Thorbjørn

AU - Litvinov, Ivan V

AU - Wang, Yang

AU - Xia, Lixin

AU - Willerslev-Olsen, Andreas

AU - Koralov, Sergei B

AU - Kopp, Katharina L

AU - Bonefeld, Charlotte M

AU - Wasik, Mariusz A

AU - Geisler, Carsten

AU - Woetmann, Anders

AU - Zhou, Youwen

AU - Sasseville, Denis

AU - Odum, Niels

PY - 2013/6/25

Y1 - 2013/6/25

N2 - Inappropriately regulated expression of IL-17A is associated with the development of inflammatory diseases and cancer. However, little is known about the role of other IL-17 family members in carcinogenesis. Here, we show that a set of malignant T-cell lines established from patients with cutaneous T-cell lymphoma (CTCL) spontaneously secrete IL-17F and that inhibitors of Jak and Stat3 are able to block that secretion. Other malignant T-cell lines produce IL-17A but not IL-17F. Upon activation, however, some of the malignant T-cell lines are able to co-express IL-17A and IL-17F leading to formation of IL-17A/F heterodimers. Clinically, we demonstrate that IL-17F mRNA expression is significantly increased in CTCL skin lesions when compared to healthy donors and patients with chronic dermatitis. IL-17A expression is also increased and a significant number of patients express high levels of both IL-17A and IL-17F. Concomitantly, we observe that the expression of the IL-17 receptor is significantly increased in CTCL skin lesions when compared to control subjects. Importantly, analysis of a historic cohort of 60 CTCL patients indicates that IL-17F expression is associated with progressive disease. These findings implicate IL-17F in the pathogenesis of CTCL and suggest that IL-17 cytokines and their receptors may serve as therapeutic targets.

AB - Inappropriately regulated expression of IL-17A is associated with the development of inflammatory diseases and cancer. However, little is known about the role of other IL-17 family members in carcinogenesis. Here, we show that a set of malignant T-cell lines established from patients with cutaneous T-cell lymphoma (CTCL) spontaneously secrete IL-17F and that inhibitors of Jak and Stat3 are able to block that secretion. Other malignant T-cell lines produce IL-17A but not IL-17F. Upon activation, however, some of the malignant T-cell lines are able to co-express IL-17A and IL-17F leading to formation of IL-17A/F heterodimers. Clinically, we demonstrate that IL-17F mRNA expression is significantly increased in CTCL skin lesions when compared to healthy donors and patients with chronic dermatitis. IL-17A expression is also increased and a significant number of patients express high levels of both IL-17A and IL-17F. Concomitantly, we observe that the expression of the IL-17 receptor is significantly increased in CTCL skin lesions when compared to control subjects. Importantly, analysis of a historic cohort of 60 CTCL patients indicates that IL-17F expression is associated with progressive disease. These findings implicate IL-17F in the pathogenesis of CTCL and suggest that IL-17 cytokines and their receptors may serve as therapeutic targets.

U2 - 10.1182/blood-2013-01-480889

DO - 10.1182/blood-2013-01-480889

M3 - Journal article

C2 - 23801634

VL - 122

SP - 943

EP - 950

JO - Blood

JF - Blood

SN - 0006-4971

IS - 6

ER -

ID: 46483103