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Epigenetic Deficiencies and Replicative Stress: Driving Cancer Cells to an Early Grave

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Cancer cell-specific synthetic lethal interactions entail promising therapeutic possibilities. In this issue of Cancer Cell, Pfister et al. describe a synthetic lethal interaction where cancer cells deficient in H3K36me3 owing to SETD2 loss-of-function mutation are strongly sensitized to inhibition of WEE1, a cell cycle controlling kinase.

OriginalsprogEngelsk
TidsskriftCancer Cell
Vol/bind28
Udgave nummer5
Sider (fra-til)545-547
Antal sider3
ISSN1535-6108
DOI
StatusUdgivet - 9 nov. 2015

ID: 165717223