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Epitope recognition patterns of thyroid peroxidase autoantibodies in healthy individuals and patients with Hashimoto's thyroiditis*

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Thyroid peroxidase antibodies (TPOAb) are markers of autoimmune thyroid disease (AITD), including Hashimoto's thyroiditis (HT), but naturally occurring TPOAb are also detectable in healthy, euthyroid individuals. In AITD, circulating TPOAb react mainly with two immunodominant regions (IDR), IDR-A and IDR-B. The present study was undertaken in order to compare the epitope recognition pattern of TPOAb in HT patients and healthy subjects.
OriginalsprogEngelsk
TidsskriftClinical Endocrinology
Vol/bind69
Udgave nummer4
Sider (fra-til)664-8
Antal sider5
ISSN0300-0664
DOI
StatusUdgivet - 1 okt. 2008

ID: 34157587