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ERG Controls B Cell Development by Promoting Igh V-to-DJ Recombination

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Søndergaard et al. demonstrate that ERG is a critical transcriptional regulator essential for B cell development. Loss of ERG leads to a marked reduction in V-to-DJ recombination at the Igh locus, precluding B cell progenitors from expressing the pre-B cell receptor, which is required for entering the final stages of B cell development.

OriginalsprogEngelsk
TidsskriftCell Reports
Vol/bind29
Udgave nummer9
Sider (fra-til)2756-2769.e6
Antal sider21
ISSN2211-1247
DOI
StatusUdgivet - 26 nov. 2019

ID: 231505814