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Exercise training alters the balance between vasoactive compounds in skeletal muscle of individuals with essential hypertension

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The effects of physical training on the formation of vasodilating and vasoconstricting compounds, as well as on related proteins important for vascular function, were examined in skeletal muscle of individuals with essential hypertension (n=10). Muscle microdialysis samples were obtained from subjects with hypertension before and after 16 weeks of physical training. Muscle dialysates were analyzed for thromboxane A(2), prostacyclin, nucleotides, and nitrite/nitrate. Protein levels of thromboxane synthase, prostacyclin synthase, cyclooxygenase 1 and 2, endothelial nitric oxide synthase (eNOS), cystathionine-¿-lyase, cytochrome P450 4A and 2C9, and the purinergic receptors P2X1 and P2Y2 were determined in skeletal muscle. The protein levels were compared with those of normotensive control subjects (n=12). Resting muscle dialysate thromboxane A(2) and prostacyclin concentrations were lower (P
OriginalsprogEngelsk
TidsskriftHypertension
Vol/bind58
Udgave nummer5
Sider (fra-til)943-949
Antal sider7
ISSN0194-911X
DOI
StatusUdgivet - 2011

Bibliografisk note

CURIS 2011 5200 089

ID: 34409077