Forskning ved Københavns Universitet - Københavns Universitet

Forside

Expression pattern of four membrane-type matrix metalloproteinases in the normal and diseased mouse mammary gland

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Both mammary gland development and mammary carcinogenesis involve extensive remodeling of the mammary gland extracellular matrix. The expression of four membrane-type matrix metalloproteinases (MT-MMPs) with matrix remodeling potential in development and tumorigenesis was evaluated by in-situ hybridization on mouse mammary gland sections. MT1-MMP and MT3-MMP were found in the mammary stroma mainly around epithelial structures in both developing and mature mammary gland. In contrast, MT2-MMP was found exclusively in the mammary epithelium. Lactating gland expressed none of the examined MT-MMPs. Mammary gland tumors expressed MT1-MMP, MT2-MMP, and MT3-MMP while MT4-MMP was not expressed in any developmental or cancerous stage analyzed here. Our results suggest that MT1-MMP, MT2-MMP, and MT3-MMP may be involved in remodeling of both the normal and diseased mammary gland either directly or indirectly by activation of other MMPs.

OriginalsprogEngelsk
TidsskriftJournal of Cellular Physiology
Vol/bind205
Udgave nummer1
Sider (fra-til)123-32
Antal sider10
ISSN0021-9541
DOI
StatusUdgivet - okt. 2005

ID: 201164157