Forskning ved Københavns Universitet - Københavns Universitet

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Factors of importance for a successful delivery system for proteins

Publikation: Bidrag til tidsskriftReviewForskningfagfællebedømt

Protein pharmaceuticals have matured into an important class of drugs, now comprising one in three novel drugs introduced on the market. However, significant gains are still to be made in reducing the costs of production, ensuring proper pharmacokinetics and efficacy, increasing patient compliance and convenience, and reducing side effects such as immunogenicity. This review summarises these issues and provides recent examples of methods to reduce costs, alter pharmacokinetics and increase patient compliance. It also discusses the increasing interest in understanding immunogenicity in order to prevent failure of the protein drug or serious life-threatening side effects due to autoimmunogenicity.
OriginalsprogEngelsk
TidsskriftExpert Opinion on Drug Delivery
Vol/bind2
Udgave nummer6
Sider (fra-til)1029-37
Antal sider9
ISSN1742-5247
DOI
StatusUdgivet - nov. 2005

ID: 44640488