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Factors regulating fat oxidation in human skeletal muscle

Publikation: Bidrag til tidsskriftReviewForskningfagfællebedømt

In modern societies, oversupply of calories leads to obesity and chronic metabolic stress, which may lead to development of disease. Oversupply of calories is often associated with elevated plasma lipid concentrations and accumulation of lipids in skeletal muscle leading to decreased insulin sensitivity. Consequently, enhanced fat oxidation might be beneficial in counteracting lipid accumulation. Exercise is the most effective way to increase fat oxidation, because it increases metabolic rate. Lipid metabolism can also be altered by dietary manipulations. Thus, a fat rich diet leads to increased potential for fat oxidation by increasing the content of several of the proteins in the fat oxidative pathway. The regulation of both exercise and diet induced lipid oxidation will be discussed in this review.
OriginalsprogEngelsk
TidsskriftObesity Reviews
Vol/bind12
Udgave nummer10
Sider (fra-til)852-858
Antal sider7
ISSN1467-7881
DOI
StatusUdgivet - 2011

Bibliografisk note

CURIS 2011 5200 119

ID: 35090077