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Fasting and postprandial serum concentrations of glycine- and taurine-conjugated bile acids in crohn's disease

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Fasting and postprandial serum concentrations of glycine and taurine conjugates of cholic, chenodeoxycholic, and deoxycholic acid were measured with a high-pressure liquid chromatographic-enzymatic assay in 17 patients with ileal Crohn's disease and in 17 controls. The postprandial concentrations of the taurine-conjugated bile acids in the patients were significantly lower than in the controls, whereas the concentrations of the glycine conjugates were not significantly different. The total glycine to taurine ratios of serum bile acids were significantly higher in the patients (means, 2.9 fasting and 4.8 postprandial) than in the controls (1.9 and 2.6). Of the patients, 65% had a postprandial total G/T ratio of serum bile acids which was above the control interval.

OriginalsprogEngelsk
BogserieScandinavian Journal of Gastroenterology
Vol/bind18
Udgave nummer3
Sider (fra-til)433-438
Antal sider6
ISSN0036-5521
DOI
StatusUdgivet - 1 jan. 1983

ID: 230032268