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FGF-2 low molecular weight selectively promotes neuritogenesis of motor neurons in vitro

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  • Allodi, Ilary
  • Laura Casals-Díaz
  • Eva Santos-Nogueira
  • Francisco Gonzalez-Perez
  • Xavier Navarro
  • Esther Udina

In this study, we screened in vitro the different capabilities of trophic factors with promising effect for enhancing selective regeneration and thus promoting specific reinnervation of target organs after peripheral nerve regeneration. We found that FGF-2 (18 kDa) was the trophic factor that exerted the most selective effect in promoting neurite outgrowth of spinal motoneurons both in terms of elongation and arborization. The mechanism underlying this effect on neuritogenesis seems related to FGF-2 enhancing the interaction between FGFR-1 and PSA-NCAM. The interaction of these two receptors is important during the early stages of neuritogenesis and pathfinding, while integrin alpha7B subunit seems to play a role during neurite stabilization.

OriginalsprogEngelsk
TidsskriftMolecular Neurobiology
Vol/bind47
Udgave nummer2
Sider (fra-til)770-781
Antal sider12
ISSN0893-7648
DOI
StatusUdgivet - 2013

ID: 227433872