Forskning ved Københavns Universitet - Københavns Universitet


Fish antibiotherapy: Bioencapsulation of flumequine using adult brine shrimp (Artemia salina)

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

  • João Gomes
  • Cristina Lobo Vilela
  • Ricardo Bexiga
  • Gonçalo D. Nunes
  • Nuno Pereira
  • Lina M. Cavaco

Optimization of antibiotic delivery strategies to aquatic environment and to the specific characteristics of the target species is essential for the improvement of bacterial infection control measures. This work aimed at standardizing the use of Artemia salina to deliver flumequine to fish as antimicrobial treatment. Adult Artemia were used to bioencapsulate flumequine. A flumequine concentration of 358 μg mL-1 was found adequate to perform bioencapsulation during 24 h without causing mortality. Antibiotic concentration in Artemia, quantified by means of a microbiological assay based on MIC determination, using Escherichia coli ATCC 25922 as control strain was 256.55 mg g-1 (±71.22). The therapeutic doses of 10 mg kg -1 BW, calculated on the basis of a consumption of about 4% BW/day, would then be delivered by the consumption of 7.8 Artemia g-1 of fish.

TidsskriftAquaculture Research
Udgave nummer6
Sider (fra-til)613-617
Antal sider5
StatusUdgivet - apr. 2007
Eksternt udgivetJa

ID: 183247133