Forskning ved Københavns Universitet - Københavns Universitet

Forside

Flavonoid intake and its association with atrial fi brillation

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Standard

Flavonoid intake and its association with atrial fi brillation. / Bondonno, Nicola P.; Murray, Kevin; Bondonno, Catherine P.; Lewis, Joshua R.; Croft, Kevin D.; Kyrø, Cecilie; Gislason, Gunnar; Tjonneland, Anne; Scalbert, Augustin; Cassidy, Aedin; Piccini, Jonathan P.; Overvad, Kim; Hodgson, Jonathan M.; Dalgaard, Frederik.

I: Clinical Nutrition, Bind 39, Nr. 12, 2020, s. 3821-3828.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Bondonno, NP, Murray, K, Bondonno, CP, Lewis, JR, Croft, KD, Kyrø, C, Gislason, G, Tjonneland, A, Scalbert, A, Cassidy, A, Piccini, JP, Overvad, K, Hodgson, JM & Dalgaard, F 2020, 'Flavonoid intake and its association with atrial fi brillation', Clinical Nutrition, bind 39, nr. 12, s. 3821-3828. https://doi.org/10.1016/j.clnu.2020.04.025

APA

Bondonno, N. P., Murray, K., Bondonno, C. P., Lewis, J. R., Croft, K. D., Kyrø, C., Gislason, G., Tjonneland, A., Scalbert, A., Cassidy, A., Piccini, J. P., Overvad, K., Hodgson, J. M., & Dalgaard, F. (2020). Flavonoid intake and its association with atrial fi brillation. Clinical Nutrition, 39(12), 3821-3828. https://doi.org/10.1016/j.clnu.2020.04.025

Vancouver

Bondonno NP, Murray K, Bondonno CP, Lewis JR, Croft KD, Kyrø C o.a. Flavonoid intake and its association with atrial fi brillation. Clinical Nutrition. 2020;39(12):3821-3828. https://doi.org/10.1016/j.clnu.2020.04.025

Author

Bondonno, Nicola P. ; Murray, Kevin ; Bondonno, Catherine P. ; Lewis, Joshua R. ; Croft, Kevin D. ; Kyrø, Cecilie ; Gislason, Gunnar ; Tjonneland, Anne ; Scalbert, Augustin ; Cassidy, Aedin ; Piccini, Jonathan P. ; Overvad, Kim ; Hodgson, Jonathan M. ; Dalgaard, Frederik. / Flavonoid intake and its association with atrial fi brillation. I: Clinical Nutrition. 2020 ; Bind 39, Nr. 12. s. 3821-3828.

Bibtex

@article{6b66a0b343284afb8fae7aa05de6d12d,
title = "Flavonoid intake and its association with atrial fi brillation",
abstract = "Background & aims: Primary prevention of atrial fibrillation (AF) through behavioural and dietary modification is a critically important and unmet need. Flavonoids are bioactive dietary compounds with promising cardiovascular health benefits. Our aim was to investigate the association between flavonoid intake and clinically apparent AF.Methods: Baseline data from 55 613 participants of the Danish Diet, Cancer and Health Study, without AF, recruited between 1993 and 1997, were cross-linked with Danish nationwide registries. Total flavonoid and flavonoid subclass intakes were calculated from validated food frequency questionnaires using the Phenol-Explorer database. Associations between flavonoid intake and incident AF (first-time hospitalization or outpatient visit) were examined using restricted cubic splines based on Cox proportional hazards models.Results: During a median [IQR] follow-up of 21 [18-22] years, 7291 participants were diagnosed with AF. Total flavonoid intake was not statistically significantly associated with risk of incident AF in the whole cohort. However, compared to the lowest quintile, a total flavonoid intake of 1000 mg/day was associated with a lower risk of AF in smokers [0.86 (0.77, 0.96)] but not in non-smokers [0.96 (0.88, 1.06)], and a lower risk of AF in high alcohol consumers [>20 g/d: 0.84 (0.75, 0.95)] but not in low-to-moderate alcohol consumers [Conclusion: Intake of flavonoids was not significantly associated with a lower risk of incident AF. However, higher intakes of flavonoids may be beneficial for those at a higher risk of developing AF. (C) 2020 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.",
keywords = "Atrial fibrillation, Flavonoids, Prospective cohort study, Primary prevention, Nutrition, Cardiovascular disease, FIBRILLATION, DIET, RISK, CANCER",
author = "Bondonno, {Nicola P.} and Kevin Murray and Bondonno, {Catherine P.} and Lewis, {Joshua R.} and Croft, {Kevin D.} and Cecilie Kyr{\o} and Gunnar Gislason and Anne Tjonneland and Augustin Scalbert and Aedin Cassidy and Piccini, {Jonathan P.} and Kim Overvad and Hodgson, {Jonathan M.} and Frederik Dalgaard",
year = "2020",
doi = "10.1016/j.clnu.2020.04.025",
language = "English",
volume = "39",
pages = "3821--3828",
journal = "Clinical Nutrition",
issn = "0261-5614",
publisher = "Elsevier",
number = "12",

}

RIS

TY - JOUR

T1 - Flavonoid intake and its association with atrial fi brillation

AU - Bondonno, Nicola P.

AU - Murray, Kevin

AU - Bondonno, Catherine P.

AU - Lewis, Joshua R.

AU - Croft, Kevin D.

AU - Kyrø, Cecilie

AU - Gislason, Gunnar

AU - Tjonneland, Anne

AU - Scalbert, Augustin

AU - Cassidy, Aedin

AU - Piccini, Jonathan P.

AU - Overvad, Kim

AU - Hodgson, Jonathan M.

AU - Dalgaard, Frederik

PY - 2020

Y1 - 2020

N2 - Background & aims: Primary prevention of atrial fibrillation (AF) through behavioural and dietary modification is a critically important and unmet need. Flavonoids are bioactive dietary compounds with promising cardiovascular health benefits. Our aim was to investigate the association between flavonoid intake and clinically apparent AF.Methods: Baseline data from 55 613 participants of the Danish Diet, Cancer and Health Study, without AF, recruited between 1993 and 1997, were cross-linked with Danish nationwide registries. Total flavonoid and flavonoid subclass intakes were calculated from validated food frequency questionnaires using the Phenol-Explorer database. Associations between flavonoid intake and incident AF (first-time hospitalization or outpatient visit) were examined using restricted cubic splines based on Cox proportional hazards models.Results: During a median [IQR] follow-up of 21 [18-22] years, 7291 participants were diagnosed with AF. Total flavonoid intake was not statistically significantly associated with risk of incident AF in the whole cohort. However, compared to the lowest quintile, a total flavonoid intake of 1000 mg/day was associated with a lower risk of AF in smokers [0.86 (0.77, 0.96)] but not in non-smokers [0.96 (0.88, 1.06)], and a lower risk of AF in high alcohol consumers [>20 g/d: 0.84 (0.75, 0.95)] but not in low-to-moderate alcohol consumers [Conclusion: Intake of flavonoids was not significantly associated with a lower risk of incident AF. However, higher intakes of flavonoids may be beneficial for those at a higher risk of developing AF. (C) 2020 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.

AB - Background & aims: Primary prevention of atrial fibrillation (AF) through behavioural and dietary modification is a critically important and unmet need. Flavonoids are bioactive dietary compounds with promising cardiovascular health benefits. Our aim was to investigate the association between flavonoid intake and clinically apparent AF.Methods: Baseline data from 55 613 participants of the Danish Diet, Cancer and Health Study, without AF, recruited between 1993 and 1997, were cross-linked with Danish nationwide registries. Total flavonoid and flavonoid subclass intakes were calculated from validated food frequency questionnaires using the Phenol-Explorer database. Associations between flavonoid intake and incident AF (first-time hospitalization or outpatient visit) were examined using restricted cubic splines based on Cox proportional hazards models.Results: During a median [IQR] follow-up of 21 [18-22] years, 7291 participants were diagnosed with AF. Total flavonoid intake was not statistically significantly associated with risk of incident AF in the whole cohort. However, compared to the lowest quintile, a total flavonoid intake of 1000 mg/day was associated with a lower risk of AF in smokers [0.86 (0.77, 0.96)] but not in non-smokers [0.96 (0.88, 1.06)], and a lower risk of AF in high alcohol consumers [>20 g/d: 0.84 (0.75, 0.95)] but not in low-to-moderate alcohol consumers [Conclusion: Intake of flavonoids was not significantly associated with a lower risk of incident AF. However, higher intakes of flavonoids may be beneficial for those at a higher risk of developing AF. (C) 2020 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.

KW - Atrial fibrillation

KW - Flavonoids

KW - Prospective cohort study

KW - Primary prevention

KW - Nutrition

KW - Cardiovascular disease

KW - FIBRILLATION

KW - DIET

KW - RISK

KW - CANCER

U2 - 10.1016/j.clnu.2020.04.025

DO - 10.1016/j.clnu.2020.04.025

M3 - Journal article

C2 - 32386860

VL - 39

SP - 3821

EP - 3828

JO - Clinical Nutrition

JF - Clinical Nutrition

SN - 0261-5614

IS - 12

ER -

ID: 254770614