Forskning ved Københavns Universitet - Københavns Universitet

Forside

Fmoc-Based Assembly of PNA Oligomers: Manual and Microwave-Assisted Automated Synthesis

Publikation: Bidrag til tidsskriftTidsskriftartikelForskning

Exploration of PNA-peptide conjugates as potential antisense antibiotics necessitates a fast and efficient synthesis protocols for amounts that facilitate determination of structure-activity relationships and in vivo studies in animal infection models. Fmoc/Boc-protected PNA monomers are here used for assembly of oligomers by optimized protocols involving either a manual synthesis method at room temperature or automated microwave-assisted coupling of monomers on a peptide synthesizer.

OriginalsprogEngelsk
TidsskriftMethods in molecular biology (Clifton, N.J.)
Vol/bind2105
Sider (fra-til)1-16
Antal sider16
ISSN1064-3745
DOI
StatusUdgivet - 2020

ID: 236605460