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Foot-and-mouth disease viruses of the O/ME-SA/Ind-2001e sublineage in Pakistan

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

  • Syed M. Jamal
  • Salman Khan
  • Nick J. Knowles
  • Jemma Wadsworth
  • Hayley M. Hicks
  • Valérie Mioulet
  • Abdelghani Bin-Tarif
  • Anna B. Ludi
  • Syed Asad Ali Shah
  • Muhammad Abubakar
  • Shumaila Manzoor
  • Muhammad Afzal
  • Michael Eschbaumer
  • Donald P. King
  • Belsham, Graham John

The presence of foot-and-mouth disease virus (FMDV) of the O/ME-SA/Ind-2001e sublineage within Pakistan was initially detected in two samples collected during 2019. Analysis of further serotype O FMDVs responsible for disease outbreaks in 2019–2020 in the country has now identified the spread of this sublineage to 10 districts within two separate provinces in North-Eastern and North-Western Pakistan. Phylogenetic analysis indicates that these viruses are closely related to those circulating in Bhutan, Nepal and India. The VP1 coding sequences of these viruses from Pakistan belong to three distinct clusters, which may indicate multiple introductions of this virus sublineage, although the routes of introduction are unknown. Vaccine matching studies against O1 Manisa, O 3039 and O TUR/5/2009 support the suitability of existing vaccine strains to control current field outbreaks, but further studies are warranted to monitor the spread and evolution of the O/ME-SA/Ind-2001e sublineage in the region. (145 words).

OriginalsprogEngelsk
TidsskriftTransboundary and Emerging Diseases
ISSN1865-1674
DOI
StatusAccepteret/In press - 2021

Bibliografisk note

Funding Information:
We thank Anja Schulz for providing technical assistance with the LFD processing and sequencing. Work of the WRLFMD is supported by the European Union (via a contracted project granted from the European Commission for the control of Foot‐and‐Mouth Disease, EuFMD). The views expressed herein can in no way be taken to reflect the official opinion of the European Union. Sequencing work at The Pirbright Institute was funded by the Department for Environment, Food and Rural Affairs (Defra) and United Kingdom [research grant SE2944]. The Pirbright Institute receives grant‐aided support from the Biotechnology and Biological Sciences Research Council of the United Kingdom [projects BBS/E/I/00007035, BBS/E/I/00007036].

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