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Fractional Flow Reserve Guided PCI in Patients With and Without Left Ventricular Hypertrophy: a DANAMI-3-PRIMULTI Sub-study

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Standard

Fractional Flow Reserve Guided PCI in Patients With and Without Left Ventricular Hypertrophy : a DANAMI-3-PRIMULTI Sub-study. / Sabbah, Muhammad; Nepper-Christensen, Lars; Lønborg, Jacob; Helqvist, Steffen; Køber, Lars; Høfsten, Dan Eik; Ahtarovski, Kiril Aleksov; Göransson, Christoffer; Kyhl, Kasper; Schoos, Mikkel Malby; Vejlstrup, Niels; Kelbæk, Henning; Engstrøm, Thomas.

I: EuroIntervention, 2020.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Sabbah, M, Nepper-Christensen, L, Lønborg, J, Helqvist, S, Køber, L, Høfsten, DE, Ahtarovski, KA, Göransson, C, Kyhl, K, Schoos, MM, Vejlstrup, N, Kelbæk, H & Engstrøm, T 2020, 'Fractional Flow Reserve Guided PCI in Patients With and Without Left Ventricular Hypertrophy: a DANAMI-3-PRIMULTI Sub-study', EuroIntervention. https://doi.org/10.4244/EIJ-D-19-00577

APA

Sabbah, M., Nepper-Christensen, L., Lønborg, J., Helqvist, S., Køber, L., Høfsten, D. E., ... Engstrøm, T. (2020). Fractional Flow Reserve Guided PCI in Patients With and Without Left Ventricular Hypertrophy: a DANAMI-3-PRIMULTI Sub-study. EuroIntervention. https://doi.org/10.4244/EIJ-D-19-00577

Vancouver

Sabbah M, Nepper-Christensen L, Lønborg J, Helqvist S, Køber L, Høfsten DE o.a. Fractional Flow Reserve Guided PCI in Patients With and Without Left Ventricular Hypertrophy: a DANAMI-3-PRIMULTI Sub-study. EuroIntervention. 2020. https://doi.org/10.4244/EIJ-D-19-00577

Author

Sabbah, Muhammad ; Nepper-Christensen, Lars ; Lønborg, Jacob ; Helqvist, Steffen ; Køber, Lars ; Høfsten, Dan Eik ; Ahtarovski, Kiril Aleksov ; Göransson, Christoffer ; Kyhl, Kasper ; Schoos, Mikkel Malby ; Vejlstrup, Niels ; Kelbæk, Henning ; Engstrøm, Thomas. / Fractional Flow Reserve Guided PCI in Patients With and Without Left Ventricular Hypertrophy : a DANAMI-3-PRIMULTI Sub-study. I: EuroIntervention. 2020.

Bibtex

@article{1f60d1690b6f4fba93d896ff71bb7684,
title = "Fractional Flow Reserve Guided PCI in Patients With and Without Left Ventricular Hypertrophy: a DANAMI-3-PRIMULTI Sub-study",
abstract = "AIMS: To investigate the correlation between fractional flow reserve (FFR) and diameter stenosis in patients with STEMI with and without left ventricular hypertrophy (LVH), and the influence of LVH on complete FFR-guided revascularization versus culprit only, in terms of risk of clinical outcome.METHODS AND RESULTS: In this DANAMI-3-PRIMULTI sub-study, 279 patients with STEMI had cardiac magnetic resonance (CMR) for assessment of left-ventricular-mass-index. Ninety-six patients had FFR evaluation of a non-culprit lesion. Diameter stenosis of the non-culprit lesion was determined with 2-dimensional quantitative-coronary-analysis. The diameter stenosis (56.9{\%} vs. 54.3{\%}, p=0.38) and FFR value (0.83 vs. 0.85, p=0.34) were significantly correlated in both groups (Spearmans ρ=-0.40 and -0.41 without LVH and with LVH, respectively; p<0.001) but was not different between patients without and with LVH (p for interaction =0.87). FFR-guided complete revascularization was associated with reduced risk of death, myocardial infarction or ischemia-driven revascularization for both patients without LVH (HR 0.42, 95{\%}CI 0.20-0.85) and for patients with LVH (HR 0.50, 95{\%}CI 0.17-0.47), with no interaction between the FFR-guided complete revascularization and LVH (p for interaction =0.82).CONCLUSIONS: LVH did not interact with the correlation between diameter stenosis and FFR and did not modify the impact of complete revascularization on the occurrence of subsequent clinical events.",
author = "Muhammad Sabbah and Lars Nepper-Christensen and Jacob L{\o}nborg and Steffen Helqvist and Lars K{\o}ber and H{\o}fsten, {Dan Eik} and Ahtarovski, {Kiril Aleksov} and Christoffer G{\"o}ransson and Kasper Kyhl and Schoos, {Mikkel Malby} and Niels Vejlstrup and Henning Kelb{\ae}k and Thomas Engstr{\o}m",
year = "2020",
doi = "10.4244/EIJ-D-19-00577",
language = "English",
journal = "EuroIntervention",
issn = "1774-024X",
publisher = "Europa Digital & Publishing",

}

RIS

TY - JOUR

T1 - Fractional Flow Reserve Guided PCI in Patients With and Without Left Ventricular Hypertrophy

T2 - a DANAMI-3-PRIMULTI Sub-study

AU - Sabbah, Muhammad

AU - Nepper-Christensen, Lars

AU - Lønborg, Jacob

AU - Helqvist, Steffen

AU - Køber, Lars

AU - Høfsten, Dan Eik

AU - Ahtarovski, Kiril Aleksov

AU - Göransson, Christoffer

AU - Kyhl, Kasper

AU - Schoos, Mikkel Malby

AU - Vejlstrup, Niels

AU - Kelbæk, Henning

AU - Engstrøm, Thomas

PY - 2020

Y1 - 2020

N2 - AIMS: To investigate the correlation between fractional flow reserve (FFR) and diameter stenosis in patients with STEMI with and without left ventricular hypertrophy (LVH), and the influence of LVH on complete FFR-guided revascularization versus culprit only, in terms of risk of clinical outcome.METHODS AND RESULTS: In this DANAMI-3-PRIMULTI sub-study, 279 patients with STEMI had cardiac magnetic resonance (CMR) for assessment of left-ventricular-mass-index. Ninety-six patients had FFR evaluation of a non-culprit lesion. Diameter stenosis of the non-culprit lesion was determined with 2-dimensional quantitative-coronary-analysis. The diameter stenosis (56.9% vs. 54.3%, p=0.38) and FFR value (0.83 vs. 0.85, p=0.34) were significantly correlated in both groups (Spearmans ρ=-0.40 and -0.41 without LVH and with LVH, respectively; p<0.001) but was not different between patients without and with LVH (p for interaction =0.87). FFR-guided complete revascularization was associated with reduced risk of death, myocardial infarction or ischemia-driven revascularization for both patients without LVH (HR 0.42, 95%CI 0.20-0.85) and for patients with LVH (HR 0.50, 95%CI 0.17-0.47), with no interaction between the FFR-guided complete revascularization and LVH (p for interaction =0.82).CONCLUSIONS: LVH did not interact with the correlation between diameter stenosis and FFR and did not modify the impact of complete revascularization on the occurrence of subsequent clinical events.

AB - AIMS: To investigate the correlation between fractional flow reserve (FFR) and diameter stenosis in patients with STEMI with and without left ventricular hypertrophy (LVH), and the influence of LVH on complete FFR-guided revascularization versus culprit only, in terms of risk of clinical outcome.METHODS AND RESULTS: In this DANAMI-3-PRIMULTI sub-study, 279 patients with STEMI had cardiac magnetic resonance (CMR) for assessment of left-ventricular-mass-index. Ninety-six patients had FFR evaluation of a non-culprit lesion. Diameter stenosis of the non-culprit lesion was determined with 2-dimensional quantitative-coronary-analysis. The diameter stenosis (56.9% vs. 54.3%, p=0.38) and FFR value (0.83 vs. 0.85, p=0.34) were significantly correlated in both groups (Spearmans ρ=-0.40 and -0.41 without LVH and with LVH, respectively; p<0.001) but was not different between patients without and with LVH (p for interaction =0.87). FFR-guided complete revascularization was associated with reduced risk of death, myocardial infarction or ischemia-driven revascularization for both patients without LVH (HR 0.42, 95%CI 0.20-0.85) and for patients with LVH (HR 0.50, 95%CI 0.17-0.47), with no interaction between the FFR-guided complete revascularization and LVH (p for interaction =0.82).CONCLUSIONS: LVH did not interact with the correlation between diameter stenosis and FFR and did not modify the impact of complete revascularization on the occurrence of subsequent clinical events.

U2 - 10.4244/EIJ-D-19-00577

DO - 10.4244/EIJ-D-19-00577

M3 - Journal article

C2 - 31746761

JO - EuroIntervention

JF - EuroIntervention

SN - 1774-024X

ER -

ID: 238483166