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From concept to in vivo testing: Microcontainers for oral drug delivery

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

This work explores the potential of polymeric micrometer sized devices (microcontainers) as oral drug delivery systems (DDS). Arrays of detachable microcontainers (D-MCs) were fabricated on a sacrificial layer to improve the handling and facilitate the collection of individual D-MCs. A model drug, ketoprofen, was loaded into the microcontainers using supercritical CO2 impregnation, followed by deposition of an enteric coating to protect the drug from the harsh gastric environment and to provide a fast release in the intestine. In vitro, in vivo and ex vivo studies were performed to assess the viability of the D-MCs as oral DDS. D-MCs improved the relative oral bioavailability by 180% within 4 h, and increased the absorption rate by 2.4 times compared to the control. This work represents a significant step forward in the translation of these devices from laboratory to clinic.

OriginalsprogEngelsk
TidsskriftJournal of Controlled Release
Vol/bind268
Sider (fra-til)343-351
Antal sider9
ISSN0168-3659
DOI
StatusUdgivet - 28 dec. 2017

ID: 188111025