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Functional identification of interneurons responsible for left-right coordination of hindlimbs in mammals

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Standard

Functional identification of interneurons responsible for left-right coordination of hindlimbs in mammals. / Butt, Simon J.B.; Kiehn, Ole.

I: Neuron, Bind 38, Nr. 6, 19.06.2003, s. 953-963.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Butt, SJB & Kiehn, O 2003, 'Functional identification of interneurons responsible for left-right coordination of hindlimbs in mammals', Neuron, bind 38, nr. 6, s. 953-963. https://doi.org/10.1016/S0896-6273(03)00353-2

APA

Butt, S. J. B., & Kiehn, O. (2003). Functional identification of interneurons responsible for left-right coordination of hindlimbs in mammals. Neuron, 38(6), 953-963. https://doi.org/10.1016/S0896-6273(03)00353-2

Vancouver

Butt SJB, Kiehn O. Functional identification of interneurons responsible for left-right coordination of hindlimbs in mammals. Neuron. 2003 jun 19;38(6):953-963. https://doi.org/10.1016/S0896-6273(03)00353-2

Author

Butt, Simon J.B. ; Kiehn, Ole. / Functional identification of interneurons responsible for left-right coordination of hindlimbs in mammals. I: Neuron. 2003 ; Bind 38, Nr. 6. s. 953-963.

Bibtex

@article{ec5cda1089c54c65862953f32b235ea3,
title = "Functional identification of interneurons responsible for left-right coordination of hindlimbs in mammals",
abstract = "Local neuronal networks that are responsible for walking are poorly characterized in mammals. Using an innovative approach to identify interneuron inputs onto motorneuron populations in a neonatal rodent spinal cord preparation, we have investigated the network responsible for left-right coordination of the hindlimbs. We demonstrate how commissural interneurons (CINs), whose axons traverse the midline to innervate contralateral neurons, are organized such that distinct flexor and extensor centers in the rostral lumbar spinal cord define activity in both flexor and extensor caudal motor pools. In addition, the nature of some connections are reconfigured on switching from rest to locomotion via a mechanism that might be associated with synaptic plasticity in the spinal cord. These results from identified pattern-generating interneurons demonstrate how interneuron populations create an effective network to underlie behavior in mammals.",
author = "Butt, {Simon J.B.} and Ole Kiehn",
year = "2003",
month = jun,
day = "19",
doi = "10.1016/S0896-6273(03)00353-2",
language = "English",
volume = "38",
pages = "953--963",
journal = "Neuron",
issn = "0896-6273",
publisher = "Cell Press",
number = "6",

}

RIS

TY - JOUR

T1 - Functional identification of interneurons responsible for left-right coordination of hindlimbs in mammals

AU - Butt, Simon J.B.

AU - Kiehn, Ole

PY - 2003/6/19

Y1 - 2003/6/19

N2 - Local neuronal networks that are responsible for walking are poorly characterized in mammals. Using an innovative approach to identify interneuron inputs onto motorneuron populations in a neonatal rodent spinal cord preparation, we have investigated the network responsible for left-right coordination of the hindlimbs. We demonstrate how commissural interneurons (CINs), whose axons traverse the midline to innervate contralateral neurons, are organized such that distinct flexor and extensor centers in the rostral lumbar spinal cord define activity in both flexor and extensor caudal motor pools. In addition, the nature of some connections are reconfigured on switching from rest to locomotion via a mechanism that might be associated with synaptic plasticity in the spinal cord. These results from identified pattern-generating interneurons demonstrate how interneuron populations create an effective network to underlie behavior in mammals.

AB - Local neuronal networks that are responsible for walking are poorly characterized in mammals. Using an innovative approach to identify interneuron inputs onto motorneuron populations in a neonatal rodent spinal cord preparation, we have investigated the network responsible for left-right coordination of the hindlimbs. We demonstrate how commissural interneurons (CINs), whose axons traverse the midline to innervate contralateral neurons, are organized such that distinct flexor and extensor centers in the rostral lumbar spinal cord define activity in both flexor and extensor caudal motor pools. In addition, the nature of some connections are reconfigured on switching from rest to locomotion via a mechanism that might be associated with synaptic plasticity in the spinal cord. These results from identified pattern-generating interneurons demonstrate how interneuron populations create an effective network to underlie behavior in mammals.

UR - http://www.scopus.com/inward/record.url?scp=0038537394&partnerID=8YFLogxK

U2 - 10.1016/S0896-6273(03)00353-2

DO - 10.1016/S0896-6273(03)00353-2

M3 - Journal article

C2 - 12818180

AN - SCOPUS:0038537394

VL - 38

SP - 953

EP - 963

JO - Neuron

JF - Neuron

SN - 0896-6273

IS - 6

ER -

ID: 194978880