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Gastrointestinal regulatory peptides in familial adenomatous polyposis

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The etiology of adenomas in the stomach and duodenum in patients with familial adenomatous polyposis (FAP) is unknown. In this study the plasma concentration of epidermal growth factor (EGF), and other gastrointestinal polypeptides with a possible trophic effect on the gastrointestinal mucosa, was unchanged before and after meal stimulation. In 3 of 7 patients an increased EGF immunoreactivity was found in duodenal adenomas. This study has not indicated that regulatory peptides are involved in development of duodenal polyps in FAP. but suggests further studies to determine the role of EGF in FAP.

OriginalsprogEngelsk
TidsskriftDigestion
Vol/bind46
Udgave nummer4
Sider (fra-til)228-232
Antal sider5
ISSN0012-2823
DOI
StatusUdgivet - 1 jan. 1990

ID: 199324522