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Gene expression profiles during beta cell maturation and after IL-1beta exposure reveal important roles of Pdx-1 and Nkx6.1 for IL-1beta sensitivity

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Maturation of the beta cells in the islets of Langerhans is dependent upon sequential activation of different transcription factors such as Pdx-1 and Nkx6.1. This maturation is associated with an acquired sensitivity to cytokines and may eventually lead to type 1 diabetes. The aims of this study were to characterise changes in mRNA expression during beta cell maturation as well as after interleukin-1beta (IL-1beta) exposure.
OriginalsprogEngelsk
TidsskriftDiabetologia
Vol/bind47
Udgave nummer12
Sider (fra-til)2185-99
Antal sider15
ISSN0012-186X
DOI
StatusUdgivet - dec. 2004
Eksternt udgivetJa

ID: 46485091