Forskning ved Københavns Universitet - Københavns Universitet

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Genetic and environmental influences on adult human height across birth cohorts from 1886 to 1994

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

  • Aline Jelenkovic
  • Yoon-Mi Hur
  • Reijo Sund
  • Yoshie Yokoyama
  • Sisira H. Siribaddana
  • Matthew Hotopf
  • Athula Sumathipala
  • Fruhling Rijsdijk
  • Qihua Tan
  • Dongfeng Zhang
  • Zengchang Pang
  • Sari Aaltonen
  • Kauko Heikkila
  • Sevgi Y. Oncel
  • Fazil Aliev
  • Esther Rebato
  • Adam D. Tarnoki
  • David L. Tarnoki
  • Kaare Christensen
  • Axel Skytthe
  • Kirsten O. Kyvik
  • Judy L. Silberg
  • Lindon J. Eaves
  • Hermine H. Maes
  • Tessa L. Cutler
  • John L. Hopper
  • Juan R. Ordonana
  • Juan F. Sanchez-Romera
  • Lucia Colodro-Conde
  • Wendy Cozen
  • Amie E. Hwang
  • Thomas M. Mack
  • Joohon Sun
  • Yun-Mi Song
  • Sarah Yang
  • Kayoung Lee
  • Carol E. Franz
  • William S. Kremen
  • Michael J. Lyons
  • Andreas Busjahn
  • Tracy L. Nelson
  • Keith E. Whitfield
  • Christian Kandler
  • Kerry L. Jang
  • Margaret Gatz
  • David A. Butler
  • Maria A. Stazi
  • Corrado Fagnani
  • Cristina D'Ippolito
  • Glen E. Duncan
  • Dedra Buchwald
  • Catherine A. Derom
  • Robert F. Vlietinck
  • Ruth J. F. Loos
  • Nicholas G. Martin
  • Sarah E. Medland
  • Grant W. Montgomery
  • Hoe-Uk Jeong
  • Gary E. Swan
  • Ruth Krasnow
  • Patrik K. E. Magnusson
  • Nancy L. Pedersen
  • Anna K. Dahl-Aslan
  • Tom A. McAdams
  • Thalia C. Eley
  • Alice M. Gregory
  • Per Tynelius
  • Laura A. Baker
  • Catherine Tuvblad
  • Gombojav Bayasgalan
  • Danshiitsoodol Narandalai
  • Paul Lichtenstein
  • Timothy D. Spector
  • Massimo Mangino
  • Genevieve Lachance
  • Meike Bartels
  • Toos C. E. M. van Beijsterveldt
  • Gonneke Willemsen
  • S. Alexandra Burt
  • Kelly L. Klump
  • Jennifer R. Harris
  • Ingunn Brandt
  • Thomas Sevenius Nilsen
  • Robert F. Krueger
  • Matt McGue
  • Shandell Pahlen
  • Robin P. Corley
  • Jacob v B. Hjelmborg
  • Jack H. Goldberg
  • Yoshinori Iwatani
  • Mikio Watanabe
  • Chika Honda
  • Fujio Inui
  • Finn Rasmussen
  • Brooke M. Huibregtse
  • Dorret I. Boomsma
  • Jaakko Kaprio
  • Karri Silventoinen
Human height variation is determined by genetic and environmental factors, but it remains unclear whether their influences differ across birth-year cohorts. We conducted an individual-based pooled analysis of 40 twin cohorts including 143,390 complete twin pairs born 1886–1994. Although genetic variance showed a generally increasing trend across the birth-year cohorts, heritability estimates (0.69-0.84 in men and 0.53-0.78 in women) did not present any clear pattern of secular changes. Comparing geographic-cultural regions (Europe, North America and Australia, and East Asia), total height variance was greatest in North America and Australia and lowest in East Asia, but no clear pattern in the heritability estimates across the birth-year cohorts emerged. Our findings do not support the hypothesis that heritability of height is lower in populations with low living standards than in affluent populations, nor that heritability of height will increase within a population as living standards improve.
OriginalsprogEngelsk
Artikelnummere20320
TidsskrifteLife
Vol/bind5
Sider (fra-til)1-14
Antal sider14
ISSN2050-084X
DOI
StatusUdgivet - 14 dec. 2016

ID: 173585464