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Genetic variations in VEGF and VEGFR2 and glioblastoma outcome

Publikation: Bidrag til tidsskriftTidsskriftartikelForskning

Standard

Genetic variations in VEGF and VEGFR2 and glioblastoma outcome. / Sjöström, S; Wibom, C; Andersson, U; Brännström, T; Broholm, H; Johansen, C; Laier, Helle Collatz; Liu, Y; Bondy, M; Henriksson, R; Nielsen, Bjørn Melin.

I: Journal of Neuro-Oncology, 30.12.2010.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskning

Harvard

Sjöström, S, Wibom, C, Andersson, U, Brännström, T, Broholm, H, Johansen, C, Laier, HC, Liu, Y, Bondy, M, Henriksson, R & Nielsen, BM 2010, 'Genetic variations in VEGF and VEGFR2 and glioblastoma outcome', Journal of Neuro-Oncology. https://doi.org/10.1007/s11060-010-0504-2

APA

Sjöström, S., Wibom, C., Andersson, U., Brännström, T., Broholm, H., Johansen, C., ... Nielsen, B. M. (2010). Genetic variations in VEGF and VEGFR2 and glioblastoma outcome. Journal of Neuro-Oncology. https://doi.org/10.1007/s11060-010-0504-2

Vancouver

Sjöström S, Wibom C, Andersson U, Brännström T, Broholm H, Johansen C o.a. Genetic variations in VEGF and VEGFR2 and glioblastoma outcome. Journal of Neuro-Oncology. 2010 dec 30. https://doi.org/10.1007/s11060-010-0504-2

Author

Sjöström, S ; Wibom, C ; Andersson, U ; Brännström, T ; Broholm, H ; Johansen, C ; Laier, Helle Collatz ; Liu, Y ; Bondy, M ; Henriksson, R ; Nielsen, Bjørn Melin. / Genetic variations in VEGF and VEGFR2 and glioblastoma outcome. I: Journal of Neuro-Oncology. 2010.

Bibtex

@article{f9707b51d71e400489bcd1d173cbd790,
title = "Genetic variations in VEGF and VEGFR2 and glioblastoma outcome",
abstract = "Vascular endothelial growth factor (VEGF) and its receptors (VEGFR) are central components in the development and progression of glioblastoma. To investigate if genetic variation in VEGF and VEGFR2 is associated with glioblastoma prognosis, we examined blood samples from 154 glioblastoma cases collected in Sweden and Denmark between 2000 and 2004. Seventeen tagging single nucleotide polymorphisms (SNPs) in VEGF and 27 in VEGFR2 were genotyped and analysed, covering 90{\%} of the genetic variability within the genes. In VEGF, we found no SNPs associated with survival. In VEGFR2, we found two SNPs significantly associated to survival, namely rs2071559 and rs12502008. However, these results are likely to be false positives due to multiple testing and could not be confirmed in a separate dataset. Overall, this study provides little evidence that VEGF and VEGFR2 polymorphisms are important for glioblastoma survival.",
author = "S Sj{\"o}str{\"o}m and C Wibom and U Andersson and T Br{\"a}nnstr{\"o}m and H Broholm and C Johansen and Laier, {Helle Collatz} and Y Liu and M Bondy and R Henriksson and Nielsen, {Bj{\o}rn Melin}",
year = "2010",
month = "12",
day = "30",
doi = "http://dx.doi.org/10.1007/s11060-010-0504-2",
language = "English",
journal = "Journal of Neuro-Oncology",
issn = "0167-594X",
publisher = "Springer",

}

RIS

TY - JOUR

T1 - Genetic variations in VEGF and VEGFR2 and glioblastoma outcome

AU - Sjöström, S

AU - Wibom, C

AU - Andersson, U

AU - Brännström, T

AU - Broholm, H

AU - Johansen, C

AU - Laier, Helle Collatz

AU - Liu, Y

AU - Bondy, M

AU - Henriksson, R

AU - Nielsen, Bjørn Melin

PY - 2010/12/30

Y1 - 2010/12/30

N2 - Vascular endothelial growth factor (VEGF) and its receptors (VEGFR) are central components in the development and progression of glioblastoma. To investigate if genetic variation in VEGF and VEGFR2 is associated with glioblastoma prognosis, we examined blood samples from 154 glioblastoma cases collected in Sweden and Denmark between 2000 and 2004. Seventeen tagging single nucleotide polymorphisms (SNPs) in VEGF and 27 in VEGFR2 were genotyped and analysed, covering 90% of the genetic variability within the genes. In VEGF, we found no SNPs associated with survival. In VEGFR2, we found two SNPs significantly associated to survival, namely rs2071559 and rs12502008. However, these results are likely to be false positives due to multiple testing and could not be confirmed in a separate dataset. Overall, this study provides little evidence that VEGF and VEGFR2 polymorphisms are important for glioblastoma survival.

AB - Vascular endothelial growth factor (VEGF) and its receptors (VEGFR) are central components in the development and progression of glioblastoma. To investigate if genetic variation in VEGF and VEGFR2 is associated with glioblastoma prognosis, we examined blood samples from 154 glioblastoma cases collected in Sweden and Denmark between 2000 and 2004. Seventeen tagging single nucleotide polymorphisms (SNPs) in VEGF and 27 in VEGFR2 were genotyped and analysed, covering 90% of the genetic variability within the genes. In VEGF, we found no SNPs associated with survival. In VEGFR2, we found two SNPs significantly associated to survival, namely rs2071559 and rs12502008. However, these results are likely to be false positives due to multiple testing and could not be confirmed in a separate dataset. Overall, this study provides little evidence that VEGF and VEGFR2 polymorphisms are important for glioblastoma survival.

U2 - http://dx.doi.org/10.1007/s11060-010-0504-2

DO - http://dx.doi.org/10.1007/s11060-010-0504-2

M3 - Journal article

JO - Journal of Neuro-Oncology

JF - Journal of Neuro-Oncology

SN - 0167-594X

ER -

ID: 34077717