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Genetics of suicide attempts in individuals with and without mental disorders: a population-based genome-wide association study

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Genetics of suicide attempts in individuals with and without mental disorders : a population-based genome-wide association study. / Erlangsen, Annette; Appadurai, Vivek; Wang, Yunpeng; Turecki, Gustavo; Mors, Ole; Werge, Thomas; Mortensen, Preben B; Starnawska, Anna; Børglum, Anders D; Schork, Andrew; Nudel, Ron; Bækvad-Hansen, Marie; Bybjerg-Grauholm, Jonas; Hougaard, David M; Thompson, Wesley K; Nordentoft, Merete; Agerbo, Esben.

I: Molecular Psychiatry, 2020.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Erlangsen, A, Appadurai, V, Wang, Y, Turecki, G, Mors, O, Werge, T, Mortensen, PB, Starnawska, A, Børglum, AD, Schork, A, Nudel, R, Bækvad-Hansen, M, Bybjerg-Grauholm, J, Hougaard, DM, Thompson, WK, Nordentoft, M & Agerbo, E 2020, 'Genetics of suicide attempts in individuals with and without mental disorders: a population-based genome-wide association study', Molecular Psychiatry. https://doi.org/10.1038/s41380-018-0218-y

APA

Erlangsen, A., Appadurai, V., Wang, Y., Turecki, G., Mors, O., Werge, T., ... Agerbo, E. (2020). Genetics of suicide attempts in individuals with and without mental disorders: a population-based genome-wide association study. Molecular Psychiatry. https://doi.org/10.1038/s41380-018-0218-y

Vancouver

Erlangsen A, Appadurai V, Wang Y, Turecki G, Mors O, Werge T o.a. Genetics of suicide attempts in individuals with and without mental disorders: a population-based genome-wide association study. Molecular Psychiatry. 2020. https://doi.org/10.1038/s41380-018-0218-y

Author

Erlangsen, Annette ; Appadurai, Vivek ; Wang, Yunpeng ; Turecki, Gustavo ; Mors, Ole ; Werge, Thomas ; Mortensen, Preben B ; Starnawska, Anna ; Børglum, Anders D ; Schork, Andrew ; Nudel, Ron ; Bækvad-Hansen, Marie ; Bybjerg-Grauholm, Jonas ; Hougaard, David M ; Thompson, Wesley K ; Nordentoft, Merete ; Agerbo, Esben. / Genetics of suicide attempts in individuals with and without mental disorders : a population-based genome-wide association study. I: Molecular Psychiatry. 2020.

Bibtex

@article{a2d85259027c480aa150f98b45397fcf,
title = "Genetics of suicide attempts in individuals with and without mental disorders: a population-based genome-wide association study",
abstract = "Family studies have shown an aggregation of suicidal behavior in families. Yet, molecular studies are needed to identify loci accounting for genetic heritability. We conducted a genome-wide association study and estimated single nucleotide polymorphisms (SNP) heritability for a suicide attempt. In a case-cohort study, national data on all individuals born in Denmark after 1981 and diagnosed with severe mental disorders prior to 2013 (n = 57,377) and individuals from the general population (n = 30,000) were obtained. After quality control, the sample consisted of 6024 cases with an incidence of suicide attempt and 44,240 controls with no record of a suicide attempt. Suggestive associations between SNPs, rs6880062 (p-value: 5.4 × 10-8) and rs6880461 (p-value: 9.5 × 10-8), and suicide attempt were identified when adjusting for socio-demographics. Adjusting for mental disorders, three significant associations, all on chromosome 20, were identified: rs4809706 (p-value: 2.8 × 10-8), rs4810824 (p-value: 3.5 × 10-8), and rs6019297 (p-value: 4.7 × 108). Sub-group analysis of cases with affective disorders revealed SNPs associated with suicide attempts when compared to the general population for gene PDE4B. All SNPs explained 4.6{\%} [CI-95: 2.9-6.3{\%}] of the variation in suicide attempt. Controlling for mental disorders reduced the heritability to 1.9{\%} [CI-95: 0.3-3.5{\%}]. Affective and autism spectrum disorders exhibited a SNP heritability of 5.6{\%} [CI-95: 1.9-9.3{\%}] and 9.6{\%} [CI-95: 1.1-18.1{\%}], respectively. Using the largest sample to date, we identified significant SNP associations with suicide attempts and support for a genetic transmission of suicide attempt, which might not solely be explained by mental disorders.",
author = "Annette Erlangsen and Vivek Appadurai and Yunpeng Wang and Gustavo Turecki and Ole Mors and Thomas Werge and Mortensen, {Preben B} and Anna Starnawska and B{\o}rglum, {Anders D} and Andrew Schork and Ron Nudel and Marie B{\ae}kvad-Hansen and Jonas Bybjerg-Grauholm and Hougaard, {David M} and Thompson, {Wesley K} and Merete Nordentoft and Esben Agerbo",
year = "2020",
doi = "10.1038/s41380-018-0218-y",
language = "English",
journal = "Molecular Psychiatry",
issn = "1359-4184",
publisher = "nature publishing group",

}

RIS

TY - JOUR

T1 - Genetics of suicide attempts in individuals with and without mental disorders

T2 - a population-based genome-wide association study

AU - Erlangsen, Annette

AU - Appadurai, Vivek

AU - Wang, Yunpeng

AU - Turecki, Gustavo

AU - Mors, Ole

AU - Werge, Thomas

AU - Mortensen, Preben B

AU - Starnawska, Anna

AU - Børglum, Anders D

AU - Schork, Andrew

AU - Nudel, Ron

AU - Bækvad-Hansen, Marie

AU - Bybjerg-Grauholm, Jonas

AU - Hougaard, David M

AU - Thompson, Wesley K

AU - Nordentoft, Merete

AU - Agerbo, Esben

PY - 2020

Y1 - 2020

N2 - Family studies have shown an aggregation of suicidal behavior in families. Yet, molecular studies are needed to identify loci accounting for genetic heritability. We conducted a genome-wide association study and estimated single nucleotide polymorphisms (SNP) heritability for a suicide attempt. In a case-cohort study, national data on all individuals born in Denmark after 1981 and diagnosed with severe mental disorders prior to 2013 (n = 57,377) and individuals from the general population (n = 30,000) were obtained. After quality control, the sample consisted of 6024 cases with an incidence of suicide attempt and 44,240 controls with no record of a suicide attempt. Suggestive associations between SNPs, rs6880062 (p-value: 5.4 × 10-8) and rs6880461 (p-value: 9.5 × 10-8), and suicide attempt were identified when adjusting for socio-demographics. Adjusting for mental disorders, three significant associations, all on chromosome 20, were identified: rs4809706 (p-value: 2.8 × 10-8), rs4810824 (p-value: 3.5 × 10-8), and rs6019297 (p-value: 4.7 × 108). Sub-group analysis of cases with affective disorders revealed SNPs associated with suicide attempts when compared to the general population for gene PDE4B. All SNPs explained 4.6% [CI-95: 2.9-6.3%] of the variation in suicide attempt. Controlling for mental disorders reduced the heritability to 1.9% [CI-95: 0.3-3.5%]. Affective and autism spectrum disorders exhibited a SNP heritability of 5.6% [CI-95: 1.9-9.3%] and 9.6% [CI-95: 1.1-18.1%], respectively. Using the largest sample to date, we identified significant SNP associations with suicide attempts and support for a genetic transmission of suicide attempt, which might not solely be explained by mental disorders.

AB - Family studies have shown an aggregation of suicidal behavior in families. Yet, molecular studies are needed to identify loci accounting for genetic heritability. We conducted a genome-wide association study and estimated single nucleotide polymorphisms (SNP) heritability for a suicide attempt. In a case-cohort study, national data on all individuals born in Denmark after 1981 and diagnosed with severe mental disorders prior to 2013 (n = 57,377) and individuals from the general population (n = 30,000) were obtained. After quality control, the sample consisted of 6024 cases with an incidence of suicide attempt and 44,240 controls with no record of a suicide attempt. Suggestive associations between SNPs, rs6880062 (p-value: 5.4 × 10-8) and rs6880461 (p-value: 9.5 × 10-8), and suicide attempt were identified when adjusting for socio-demographics. Adjusting for mental disorders, three significant associations, all on chromosome 20, were identified: rs4809706 (p-value: 2.8 × 10-8), rs4810824 (p-value: 3.5 × 10-8), and rs6019297 (p-value: 4.7 × 108). Sub-group analysis of cases with affective disorders revealed SNPs associated with suicide attempts when compared to the general population for gene PDE4B. All SNPs explained 4.6% [CI-95: 2.9-6.3%] of the variation in suicide attempt. Controlling for mental disorders reduced the heritability to 1.9% [CI-95: 0.3-3.5%]. Affective and autism spectrum disorders exhibited a SNP heritability of 5.6% [CI-95: 1.9-9.3%] and 9.6% [CI-95: 1.1-18.1%], respectively. Using the largest sample to date, we identified significant SNP associations with suicide attempts and support for a genetic transmission of suicide attempt, which might not solely be explained by mental disorders.

U2 - 10.1038/s41380-018-0218-y

DO - 10.1038/s41380-018-0218-y

M3 - Journal article

C2 - 30116032

JO - Molecular Psychiatry

JF - Molecular Psychiatry

SN - 1359-4184

ER -

ID: 218720619