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Ginkgolides: selective acetylations, translactonization, and biological evaluation

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Protocols for selective acetylation of the hydroxyl groups of ginkgolide C have been developed. These acetylations have given rise to various ginkgolide C acetates and iso-ginkgolide C acetates, the latter having a rearranged skeleton resulting from translactonization. These acetyl derivatives, as well as ginkgolides A and B acetates have been investigated for their ability to bind to a cloned platelet-activating factor (PAF) receptor.
OriginalsprogEngelsk
TidsskriftJournal of Organic Chemistry
Vol/bind67
Udgave nummer13
Sider (fra-til)4623-4626
Antal sider4
ISSN0022-3263
DOI
StatusUdgivet - 28 jun. 2002
Eksternt udgivetJa

ID: 45810405