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Girls may have lower levels of maternal measles antibodies and higher risk of subclinical measles infection before the age of measles vaccination

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Girls may have lower levels of maternal measles antibodies and higher risk of subclinical measles infection before the age of measles vaccination. / Martins, Cesario; Bale, Carlitos; Garly, May-Lill; Rodrigues, Amabelia; Lisse, Ida M; Andersen, Andreas; Eriksson, Mia; Benn, Christine S; Whittle, Hilton; Aaby, Peter.

I: Vaccine, Bind 27, Nr. 38, 2009, s. 5220-5.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Martins, C, Bale, C, Garly, M-L, Rodrigues, A, Lisse, IM, Andersen, A, Eriksson, M, Benn, CS, Whittle, H & Aaby, P 2009, 'Girls may have lower levels of maternal measles antibodies and higher risk of subclinical measles infection before the age of measles vaccination', Vaccine, bind 27, nr. 38, s. 5220-5. https://doi.org/10.1016/j.vaccine.2009.06.076

APA

Martins, C., Bale, C., Garly, M-L., Rodrigues, A., Lisse, I. M., Andersen, A., Eriksson, M., Benn, C. S., Whittle, H., & Aaby, P. (2009). Girls may have lower levels of maternal measles antibodies and higher risk of subclinical measles infection before the age of measles vaccination. Vaccine, 27(38), 5220-5. https://doi.org/10.1016/j.vaccine.2009.06.076

Vancouver

Martins C, Bale C, Garly M-L, Rodrigues A, Lisse IM, Andersen A o.a. Girls may have lower levels of maternal measles antibodies and higher risk of subclinical measles infection before the age of measles vaccination. Vaccine. 2009;27(38):5220-5. https://doi.org/10.1016/j.vaccine.2009.06.076

Author

Martins, Cesario ; Bale, Carlitos ; Garly, May-Lill ; Rodrigues, Amabelia ; Lisse, Ida M ; Andersen, Andreas ; Eriksson, Mia ; Benn, Christine S ; Whittle, Hilton ; Aaby, Peter. / Girls may have lower levels of maternal measles antibodies and higher risk of subclinical measles infection before the age of measles vaccination. I: Vaccine. 2009 ; Bind 27, Nr. 38. s. 5220-5.

Bibtex

@article{4df95eb0836811df928f000ea68e967b,
title = "Girls may have lower levels of maternal measles antibodies and higher risk of subclinical measles infection before the age of measles vaccination",
abstract = "BACKGROUND: Previous studies have suggested that girls may have lower maternal measles antibody levels than boys. Girls might therefore be more likely to contract measles infection before the normal age of measles vaccination at 9 months of age. METHODS: In connection with a clinical trial of different measles vaccination strategies, we collected pre-measles vaccination blood samples at 4.5 months of age from two subgroups of children. Samples from these children were used to assess possible differences in maternal antibody levels for boys and girls. At 9 months of age another subgroup of children was sampled before the normal measles vaccination; these samples were used to assess the frequency of subclinical measles infection among boys and girls. RESULTS: We determined measles-specific antibody levels for 812 children at 4.5 months of age and for 896 children at 9 months of age. At 4.5 months of age girls were less likely to have protective maternal antibody levels, the male-female ratio for protective antibody level being 1.23 (1.00-1.51). Among children sampled at 9 months of age, girls were more likely to have protective levels, the female-male ratio for having protective antibody levels being 1.65 (0.98-2.78) (p=0.054) and the geometric mean titre was significantly higher for girls (p=0.007). Children who lived in houses with known measles cases were more likely to have protective levels at 9 months of age even though they had not reported measles infection. Since we had excluded children with known measles infection, girls may have been more likely to have had subclinical measles infection. Combining clinical and possible subclinical measles infection, girls tended to be more likely than boys to contract measles infection before 9 months of age, the RR being 1.36 (0.97-1.90). CONCLUSIONS: Girls lost maternal measles antibodies more rapidly than boys and well before 9 months of age. They may be more likely to contract subclinical measles infection before the current age of measles vaccination.",
author = "Cesario Martins and Carlitos Bale and May-Lill Garly and Amabelia Rodrigues and Lisse, {Ida M} and Andreas Andersen and Mia Eriksson and Benn, {Christine S} and Hilton Whittle and Peter Aaby",
note = "Keywords: Antibodies, Viral; Female; Hemagglutination Inhibition Tests; Humans; Immunity, Maternally-Acquired; Immunization Programs; Infant; Male; Measles; Measles Vaccine; Population Surveillance; Randomized Controlled Trials as Topic; Risk Factors; Sex Factors",
year = "2009",
doi = "10.1016/j.vaccine.2009.06.076",
language = "English",
volume = "27",
pages = "5220--5",
journal = "Vaccine",
issn = "0264-410X",
publisher = "Elsevier",
number = "38",

}

RIS

TY - JOUR

T1 - Girls may have lower levels of maternal measles antibodies and higher risk of subclinical measles infection before the age of measles vaccination

AU - Martins, Cesario

AU - Bale, Carlitos

AU - Garly, May-Lill

AU - Rodrigues, Amabelia

AU - Lisse, Ida M

AU - Andersen, Andreas

AU - Eriksson, Mia

AU - Benn, Christine S

AU - Whittle, Hilton

AU - Aaby, Peter

N1 - Keywords: Antibodies, Viral; Female; Hemagglutination Inhibition Tests; Humans; Immunity, Maternally-Acquired; Immunization Programs; Infant; Male; Measles; Measles Vaccine; Population Surveillance; Randomized Controlled Trials as Topic; Risk Factors; Sex Factors

PY - 2009

Y1 - 2009

N2 - BACKGROUND: Previous studies have suggested that girls may have lower maternal measles antibody levels than boys. Girls might therefore be more likely to contract measles infection before the normal age of measles vaccination at 9 months of age. METHODS: In connection with a clinical trial of different measles vaccination strategies, we collected pre-measles vaccination blood samples at 4.5 months of age from two subgroups of children. Samples from these children were used to assess possible differences in maternal antibody levels for boys and girls. At 9 months of age another subgroup of children was sampled before the normal measles vaccination; these samples were used to assess the frequency of subclinical measles infection among boys and girls. RESULTS: We determined measles-specific antibody levels for 812 children at 4.5 months of age and for 896 children at 9 months of age. At 4.5 months of age girls were less likely to have protective maternal antibody levels, the male-female ratio for protective antibody level being 1.23 (1.00-1.51). Among children sampled at 9 months of age, girls were more likely to have protective levels, the female-male ratio for having protective antibody levels being 1.65 (0.98-2.78) (p=0.054) and the geometric mean titre was significantly higher for girls (p=0.007). Children who lived in houses with known measles cases were more likely to have protective levels at 9 months of age even though they had not reported measles infection. Since we had excluded children with known measles infection, girls may have been more likely to have had subclinical measles infection. Combining clinical and possible subclinical measles infection, girls tended to be more likely than boys to contract measles infection before 9 months of age, the RR being 1.36 (0.97-1.90). CONCLUSIONS: Girls lost maternal measles antibodies more rapidly than boys and well before 9 months of age. They may be more likely to contract subclinical measles infection before the current age of measles vaccination.

AB - BACKGROUND: Previous studies have suggested that girls may have lower maternal measles antibody levels than boys. Girls might therefore be more likely to contract measles infection before the normal age of measles vaccination at 9 months of age. METHODS: In connection with a clinical trial of different measles vaccination strategies, we collected pre-measles vaccination blood samples at 4.5 months of age from two subgroups of children. Samples from these children were used to assess possible differences in maternal antibody levels for boys and girls. At 9 months of age another subgroup of children was sampled before the normal measles vaccination; these samples were used to assess the frequency of subclinical measles infection among boys and girls. RESULTS: We determined measles-specific antibody levels for 812 children at 4.5 months of age and for 896 children at 9 months of age. At 4.5 months of age girls were less likely to have protective maternal antibody levels, the male-female ratio for protective antibody level being 1.23 (1.00-1.51). Among children sampled at 9 months of age, girls were more likely to have protective levels, the female-male ratio for having protective antibody levels being 1.65 (0.98-2.78) (p=0.054) and the geometric mean titre was significantly higher for girls (p=0.007). Children who lived in houses with known measles cases were more likely to have protective levels at 9 months of age even though they had not reported measles infection. Since we had excluded children with known measles infection, girls may have been more likely to have had subclinical measles infection. Combining clinical and possible subclinical measles infection, girls tended to be more likely than boys to contract measles infection before 9 months of age, the RR being 1.36 (0.97-1.90). CONCLUSIONS: Girls lost maternal measles antibodies more rapidly than boys and well before 9 months of age. They may be more likely to contract subclinical measles infection before the current age of measles vaccination.

U2 - 10.1016/j.vaccine.2009.06.076

DO - 10.1016/j.vaccine.2009.06.076

M3 - Journal article

C2 - 19596409

VL - 27

SP - 5220

EP - 5225

JO - Vaccine

JF - Vaccine

SN - 0264-410X

IS - 38

ER -

ID: 20572707